GATA3

From Wikipedia, the free encyclopedia


GATA binding protein 3
Identifiers
Symbol(s) GATA3; HDR; MGC2346; MGC5199; MGC5445
External IDs OMIM: 131320 MGI: 95663 HomoloGene: 1550
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2625 14462
Ensembl ENSG00000107485 ENSMUSG00000015619
Uniprot P23771 Q3TZD6
Refseq NM_001002295 (mRNA)
NP_001002295 (protein)		 NM_008091 (mRNA)
NP_032117 (protein)
Location Chr 10: 8.14 - 8.16 Mb Chr 2: 9.77 - 9.8 Mb
Pubmed search [1] [2]

GATA binding protein 3, also known as GATA3, is a human gene.[1]


Contents

[edit] See also

[edit] References

  1. ^ Entrez Gene: GATA3 GATA binding protein 3.

[edit] Further reading

  • Naylor MJ, Ormandy CJ (2007). "Gata-3 and mammary cell fate.". Breast Cancer Res. 9 (2): 302. doi:10.1186/bcr1661. PMID 17381824. 
  • Ho IC, Vorhees P, Marin N, et al. (1991). "Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene.". EMBO J. 10 (5): 1187–92. PMID 1827068. 
  • Marine J, Winoto A (1991). "The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements.". Proc. Natl. Acad. Sci. U.S.A. 88 (16): 7284–8. PMID 1871134. 
  • Ko LJ, Yamamoto M, Leonard MW, et al. (1991). "Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer.". Mol. Cell. Biol. 11 (5): 2778–84. PMID 2017177. 
  • Joulin V, Bories D, Eléouet JF, et al. (1991). "A T-cell specific TCR delta DNA binding protein is a member of the human GATA family.". EMBO J. 10 (7): 1809–16. PMID 2050118. 
  • Siegel MD, Zhang DH, Ray P, Ray A (1995). "Activation of the interleukin-5 promoter by cAMP in murine EL-4 cells requires the GATA-3 and CLE0 elements.". J. Biol. Chem. 270 (41): 24548–55. PMID 7592673. 
  • Labastie MC, Bories D, Chabret C, et al. (1994). "Structure and expression of the human GATA3 gene.". Genomics 21 (1): 1–6. doi:10.1006/geno.1994.1217. PMID 8088776. 
  • Ono Y, Fukuhara N, Yoshie O (1997). "Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL.". J. Biol. Chem. 272 (7): 4576–81. PMID 9020185. 
  • Ono Y, Fukuhara N, Yoshie O (1998). "TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3.". Mol. Cell. Biol. 18 (12): 6939–50. PMID 9819382. 
  • Yang GP, Ross DT, Kuang WW, et al. (1999). "Combining SSH and cDNA microarrays for rapid identification of differentially expressed genes.". Nucleic Acids Res. 27 (6): 1517–23. PMID 10037815. 
  • Blumenthal SG, Aichele G, Wirth T, et al. (1999). "Regulation of the human interleukin-5 promoter by Ets transcription factors. Ets1 and Ets2, but not Elf-1, cooperate with GATA3 and HTLV-I Tax1.". J. Biol. Chem. 274 (18): 12910–6. PMID 10212281. 
  • Van Esch H, Groenen P, Nesbit MA, et al. (2000). "GATA3 haplo-insufficiency causes human HDR syndrome.". Nature 406 (6794): 419–22. doi:10.1038/35019088. PMID 10935639. 
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863. 
  • Muroya K, Hasegawa T, Ito Y, et al. (2001). "GATA3 abnormalities and the phenotypic spectrum of HDR syndrome.". J. Med. Genet. 38 (6): 374–80. PMID 11389161. 
  • Crawford SE, Qi C, Misra P, et al. (2002). "Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors.". J. Biol. Chem. 277 (5): 3585–92. doi:10.1074/jbc.M107995200. PMID 11724781. 
  • Kieffer LJ, Greally JM, Landres I, et al. (2002). "Identification of a candidate regulatory region in the human CD8 gene complex by colocalization of DNase I hypersensitive sites and matrix attachment regions which bind SATB1 and GATA-3.". J. Immunol. 168 (8): 3915–22. PMID 11937547. 
  • Asnagli H, Afkarian M, Murphy KM (2002). "Cutting edge: Identification of an alternative GATA-3 promoter directing tissue-specific gene expression in mouse and human.". J. Immunol. 168 (9): 4268–71. PMID 11970965. 
  • Steenbergen RD, OudeEngberink VE, Kramer D, et al. (2002). "Down-regulation of GATA-3 expression during human papillomavirus-mediated immortalization and cervical carcinogenesis.". Am. J. Pathol. 160 (6): 1945–51. PMID 12057898. 
  • Höfer T, Nathansen H, Löhning M, et al. (2002). "GATA-3 transcriptional imprinting in Th2 lymphocytes: a mathematical model.". Proc. Natl. Acad. Sci. U.S.A. 99 (14): 9364–8. doi:10.1073/pnas.142284699. PMID 12087127. 
  • Karunaratne A, Hargrave M, Poh A, Yamada T (2002). "GATA proteins identify a novel ventral interneuron subclass in the developing chick spinal cord.". Dev. Biol. 249 (1): 30–43. PMID 12217316. 

[edit] External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD