GTF2F1

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General transcription factor IIF, polypeptide 1, 74kDa
PDB rendering based on 1f3u.
Available structures: 1f3u, 1i27, 1j2x, 1nha, 1onv
Identifiers
Symbol(s) GTF2F1; BTF4; RAP74; TF2F1; TFIIF
External IDs OMIM: 189968 MGI: 1923848 HomoloGene: 1585
Orthologs
Human Mouse
Entrez 2962 98053
Ensembl ENSG00000125651 ENSMUSG00000002658
Uniprot P35269 Q8R5B7
Refseq NM_002096 (mRNA)
NP_002087 (protein)		 NM_133801 (mRNA)
NP_598562 (protein)
Location Chr 19: 6.24 - 6.34 Mb Chr 17: 56.69 - 56.7 Mb
Pubmed search [1] [2]

General transcription factor IIF, polypeptide 1, 74kDa, also known as GTF2F1, is a human gene.[1]


Contents

[edit] See also

[edit] References

  1. ^ Entrez Gene: GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa.

[edit] Further reading

  • Kato H, Sumimoto H, Pognonec P, et al. (1992). "HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors.". Genes Dev. 6 (4): 655-66. PMID 1559613. 
  • Aso T, Vasavada HA, Kawaguchi T, et al. (1992). "Characterization of cDNA for the large subunit of the transcription initiation factor TFIIF.". Nature 355 (6359): 461-4. doi:10.1038/355461a0. PMID 1734283. 
  • Finkelstein A, Kostrub CF, Li J, et al. (1992). "A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II.". Nature 355 (6359): 464-7. doi:10.1038/355464a0. PMID 1734284. 
  • Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.". Nature 377 (6547 Suppl): 3-174. PMID 7566098. 
  • Ruppert S, Tjian R (1995). "Human TAFII250 interacts with RAP74: implications for RNA polymerase II initiation.". Genes Dev. 9 (22): 2747-55. PMID 7590250. 
  • Hisatake K, Ohta T, Takada R, et al. (1995). "Evolutionary conservation of human TATA-binding-polypeptide-associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors.". Proc. Natl. Acad. Sci. U.S.A. 92 (18): 8195-9. PMID 7667268. 
  • Joliot V, Demma M, Prywes R (1995). "Interaction with RAP74 subunit of TFIIF is required for transcriptional activation by serum response factor.". Nature 373 (6515): 632-5. doi:10.1038/373632a0. PMID 7854423. 
  • Zhu H, Joliot V, Prywes R (1994). "Role of transcription factor TFIIF in serum response factor-activated transcription.". J. Biol. Chem. 269 (5): 3489-97. PMID 8106390. 
  • Yonaha M, Aso T, Kobayashi Y, et al. (1993). "Domain structure of a human general transcription initiation factor, TFIIF.". Nucleic Acids Res. 21 (2): 273-9. PMID 8441635. 
  • Aso T, Tsai P, Kawaguchi T, et al. (1993). "Assignment of the human GTF2F1 gene to chromosome 19p13.3.". Genomics 16 (1): 252-3. doi:10.1006/geno.1993.1168. PMID 8486367. 
  • Dikstein R, Ruppert S, Tjian R (1996). "TAFII250 is a bipartite protein kinase that phosphorylates the base transcription factor RAP74.". Cell 84 (5): 781-90. PMID 8625415. 
  • Fang SM, Burton ZF (1996). "RNA polymerase II-associated protein (RAP) 74 binds transcription factor (TF) IIB and blocks TFIIB-RAP30 binding.". J. Biol. Chem. 271 (20): 11703-9. PMID 8662660. 
  • McEwan IJ, Dahlman-Wright K, Ford J, Wright AP (1996). "Functional interaction of the c-Myc transactivation domain with the TATA binding protein: evidence for an induced fit model of transactivation domain folding.". Biochemistry 35 (29): 9584-93. doi:10.1021/bi960793v. PMID 8755740. 
  • Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat.". Science 274 (5287): 605-10. PMID 8849451. 
  • Parada CA, Roeder RG (1996). "Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain.". Nature 384 (6607): 375-8. doi:10.1038/384375a0. PMID 8934526. 
  • Cujec TP, Cho H, Maldonado E, et al. (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme.". Mol. Cell. Biol. 17 (4): 1817-23. PMID 9121429. 
  • Scully R, Anderson SF, Chao DM, et al. (1997). "BRCA1 is a component of the RNA polymerase II holoenzyme.". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605-10. PMID 9159119. 
  • McEwan IJ, Gustafsson J (1997). "Interaction of the human androgen receptor transactivation function with the general transcription factor TFIIF.". Proc. Natl. Acad. Sci. U.S.A. 94 (16): 8485-90. PMID 9238003. 
  • Newberry EP, Latifi T, Battaile JT, Towler DA (1997). "Structure-function analysis of Msx2-mediated transcriptional suppression.". Biochemistry 36 (34): 10451-62. doi:10.1021/bi971008x. PMID 9265625. 
  • O'Brien T, Tjian R (1998). "Functional analysis of the human TAFII250 N-terminal kinase domain.". Mol. Cell 1 (6): 905-11. PMID 9660973. 

[edit] External links


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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD