ING1

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Inhibitor of growth family, member 1
Identifiers
Symbol(s) ING1; p24ING1c; p33; p33ING1; p33ING1b; p47; p47ING1a
External IDs OMIM: 601566 MGI: 1349481 HomoloGene: 40119
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 3621 26356
Ensembl ENSG00000153487 ENSMUSG00000045969
Uniprot Q9UK53 Q3ULE3
Refseq NM_005537 (mRNA)
NP_005528 (protein)		 XM_976418 (mRNA)
XP_981512 (protein)
Location Chr 13: 110.16 - 110.17 Mb Chr 8: 11.56 - 11.56 Mb
Pubmed search [1] [2]

Inhibitor of growth family, member 1, also known as ING1, is a human gene.[1]

This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.[1]

[edit] References

  1. ^ a b Entrez Gene: ING1 inhibitor of growth family, member 1.

[edit] Further reading

  • Campos EI, Chin MY, Kuo WH, Li G (2004). "Biological functions of the ING family tumor suppressors.". Cell. Mol. Life Sci. 61 (19-20): 2597–613. doi:10.1007/s00018-004-4199-4. PMID 15526165. 
  • Garkavtsev I, Kazarov A, Gudkov A, Riabowol K (1997). "Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation.". Nat. Genet. 14 (4): 415–20. doi:10.1038/ng1296-415. PMID 8944021. 
  • Helbing CC, Veillette C, Riabowol K, et al. (1997). "A novel candidate tumor suppressor, ING1, is involved in the regulation of apoptosis.". Cancer Res. 57 (7): 1255–8. PMID 9102209. 
  • Garkavtsev I, Riabowol K (1997). "Extension of the replicative life span of human diploid fibroblasts by inhibition of the p33ING1 candidate tumor suppressor.". Mol. Cell. Biol. 17 (4): 2014–9. PMID 9121449. 
  • Garkavtsev I, Demetrick D, Riabowol K (1997). "Cellular localization and chromosome mapping of a novel candidate tumor suppressor gene (ING1).". Cytogenet. Cell Genet. 76 (3-4): 176–8. PMID 9186514. 
  • Zeremski M, Horrigan SK, Grigorian IA, et al. (1997). "Localization of the candidate tumor suppressor gene ING1 to human chromosome 13q34.". Somat. Cell Mol. Genet. 23 (3): 233–6. PMID 9330636. 
  • Garkavtsev I, Grigorian IA, Ossovskaya VS, et al. (1998). "The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control.". Nature 391 (6664): 295–8. doi:10.1038/34675. PMID 9440695. 
  • Shinoura N, Muramatsu Y, Nishimura M, et al. (1999). "Adenovirus-mediated transfer of p33ING1 with p53 drastically augments apoptosis in gliomas.". Cancer Res. 59 (21): 5521–8. PMID 10554029. 
  • Jäger D, Stockert E, Scanlan MJ, et al. (2000). "Cancer-testis antigens and ING1 tumor suppressor gene product are breast cancer antigens: characterization of tissue-specific ING1 transcripts and a homologue gene.". Cancer Res. 59 (24): 6197–204. PMID 10626813. 
  • Sanchez-Cespedes M, Okami K, Cairns P, Sidransky D (2000). "Molecular analysis of the candidate tumor suppressor gene ING1 in human head and neck tumors with 13q deletions.". Genes Chromosomes Cancer 27 (3): 319–22. PMID 10679922. 
  • Tokunaga E, Maehara Y, Oki E, et al. (2000). "Diminished expression of ING1 mRNA and the correlation with p53 expression in breast cancers.". Cancer Lett. 152 (1): 15–22. PMID 10754201. 
  • Baranova AV, Ivanov DV, Makeeva NV, et al. (2000). "[Genomic organization of the suppressor gene for tumor growth ING1]". Mol. Biol. (Mosk.) 34 (2): 263–9. PMID 10779953. 
  • Saito A, Furukawa T, Fukushige S, et al. (2000). "p24/ING1-ALT1 and p47/ING1-ALT2, distinct alternative transcripts of p33/ING1.". J. Hum. Genet. 45 (3): 177–81. PMID 10807544. 
  • Gunduz M, Ouchida M, Fukushima K, et al. (2000). "Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas.". Cancer Res. 60 (12): 3143–6. PMID 10866301. 
  • Skowyra D, Zeremski M, Neznanov N, et al. (2001). "Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex.". J. Biol. Chem. 276 (12): 8734–9. doi:10.1074/jbc.M007664200. PMID 11118440. 
  • Nagashima M, Shiseki M, Miura K, et al. (2001). "DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53.". Proc. Natl. Acad. Sci. U.S.A. 98 (17): 9671–6. doi:10.1073/pnas.161151798. PMID 11481424. 
  • Scott M, Bonnefin P, Vieyra D, et al. (2001). "UV-induced binding of ING1 to PCNA regulates the induction of apoptosis.". J. Cell. Sci. 114 (Pt 19): 3455–62. PMID 11682605. 
  • Kuzmichev A, Zhang Y, Erdjument-Bromage H, et al. (2002). "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1).". Mol. Cell. Biol. 22 (3): 835–48. PMID 11784859. 
  • Nouman GS, Angus B, Lunec J, et al. (2002). "Comparative assessment expression of the inhibitor of growth 1 gene (ING1) in normal and neoplastic tissues.". Hybrid. Hybridomics 21 (1): 1–10. doi:10.1089/15368590252917584. PMID 11991811. 
  • Bromidge T, Lynas C (2002). "Relative levels of alternative transcripts of the ING1 gene and lack of mutations of p33/ING1 in haematological malignancies.". Leuk. Res. 26 (7): 631–5. PMID 12008079. 

[edit] External links


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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD