BHLHB2

From Wikipedia, the free encyclopedia


Basic helix-loop-helix domain containing, class B, 2
Identifiers
Symbol(s) BHLHB2; DEC1; SHARP-2; STRA13; Stra14
External IDs OMIM: 604256 MGI: 1097714 HomoloGene: 2722
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 8553 20893
Ensembl ENSG00000134107 ENSMUSG00000030103
Uniprot O14503 Q52L58
Refseq NM_003670 (mRNA)
NP_003661 (protein)		 NM_011498 (mRNA)
NP_035628 (protein)
Location Chr 3: 5 - 5 Mb Chr 6: 108.63 - 108.63 Mb
Pubmed search [1] [2]

Basic helix-loop-helix domain containing, class B, 2, also known as BHLHB2, is a human gene.[1]

DEC1 encodes a basic helix-loop-helix protein expressed in various tissues. Expression in the chondrocytes is responsive to the addition of Bt2cAMP. Differentiated embryo chondrocyte expressed gene 1 is believed to be involved in the control of cell differentiation.[1]

[edit] References

  1. ^ a b Entrez Gene: BHLHB2 basic helix-loop-helix domain containing, class B, 2.

[edit] Further reading

  • Shen M, Kawamoto T, Yan W, et al. (1997). "Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes.". Biochem. Biophys. Res. Commun. 236 (2): 294–8. doi:10.1006/bbrc.1997.6960. PMID 9240428. 
  • Antonevich T, Taneja R (1999). "Assignment1 of the human Stra13 gene (STRA13) to chromosome 3p26 by in situ hybridization.". Cytogenet. Cell Genet. 85 (3-4): 254–5. PMID 10449910. 
  • Teramoto M, Nakamasu K, Noshiro M, et al. (2001). "Gene structure and chromosomal location of a human bHLH transcriptional factor DEC1 x Stra13 x SHARP-2/BHLHB2.". J. Biochem. 129 (3): 391–6. PMID 11226878. 
  • Ivanova AV, Ivanov SV, Danilkovitch-Miagkova A, Lerman MI (2001). "Regulation of STRA13 by the von Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation pathway.". J. Biol. Chem. 276 (18): 15306–15. doi:10.1074/jbc.M010516200. PMID 11278694. 
  • Sun H, Lu B, Li RQ, et al. (2001). "Defective T cell activation and autoimmune disorder in Stra13-deficient mice.". Nat. Immunol. 2 (11): 1040–7. doi:10.1038/ni721. PMID 11668339. 
  • Yoon DY, Buchler P, Saarikoski ST, et al. (2001). "Identification of genes differentially induced by hypoxia in pancreatic cancer cells.". Biochem. Biophys. Res. Commun. 288 (4): 882–6. doi:10.1006/bbrc.2001.5867. PMID 11688991. 
  • Li Y, Zhang H, Xie M, et al. (2002). "Abundant expression of Dec1/stra13/sharp2 in colon carcinoma: its antagonizing role in serum deprivation-induced apoptosis and selective inhibition of procaspase activation.". Biochem. J. 367 (Pt 2): 413–22. doi:10.1042/BJ20020514. PMID 12119049. 
  • St-Pierre B, Flock G, Zacksenhaus E, Egan SE (2003). "Stra13 homodimers repress transcription through class B E-box elements.". J. Biol. Chem. 277 (48): 46544–51. doi:10.1074/jbc.M111652200. PMID 12297495. 
  • Miyazaki K, Kawamoto T, Tanimoto K, et al. (2003). "Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes.". J. Biol. Chem. 277 (49): 47014–21. doi:10.1074/jbc.M204938200. PMID 12354771. 
  • Shen M, Yoshida E, Yan W, et al. (2003). "Basic helix-loop-helix protein DEC1 promotes chondrocyte differentiation at the early and terminal stages.". J. Biol. Chem. 277 (51): 50112–20. doi:10.1074/jbc.M206771200. PMID 12384505. 
  • Honma S, Kawamoto T, Takagi Y, et al. (2002). "Dec1 and Dec2 are regulators of the mammalian molecular clock.". Nature 419 (6909): 841–4. doi:10.1038/nature01123. PMID 12397359. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Li Y, Xie M, Song X, et al. (2003). "DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter.". J. Biol. Chem. 278 (19): 16899–907. doi:10.1074/jbc.M300596200. PMID 12624110. 
  • Giatromanolaki A, Koukourakis MI, Sivridis E, et al. (2003). "DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer.". J. Pathol. 200 (2): 222–8. doi:10.1002/path.1330. PMID 12754744. 
  • Ivanova AV, Ivanov SV, Zhang X, et al. (2004). "STRA13 interacts with STAT3 and modulates transcription of STAT3-dependent targets.". J. Mol. Biol. 340 (4): 641–53. doi:10.1016/j.jmb.2004.05.025. PMID 15223310. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Sato F, Kawamoto T, Fujimoto K, et al. (2005). "Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1.". Eur. J. Biochem. 271 (22): 4409–19. doi:10.1111/j.1432-1033.2004.04379.x. PMID 15560782. 
  • Ivanova AV, Ivanov SV, Lerman ML (2005). "Association, mutual stabilization, and transcriptional activity of the STRA13 and MSP58 proteins.". Cell. Mol. Life Sci. 62 (4): 471–84. doi:10.1007/s00018-004-4423-2. PMID 15719173. 
  • Ivanova A, Liao SY, Lerman MI, et al. (2006). "STRA13 expression and subcellular localisation in normal and tumour tissues: implications for use as a diagnostic and differentiation marker.". J. Med. Genet. 42 (7): 565–76. doi:10.1136/jmg.2004.029835. PMID 15994878. 
  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 

[edit] External links


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v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD