GTF2A1

From Wikipedia, the free encyclopedia


General transcription factor IIA, 1, 19/37kDa
PDB rendering based on 1nvp.
Available structures: 1nvp
Identifiers
Symbol(s) GTF2A1; MGC129969; MGC129970; TF2A1; TFIIA
External IDs OMIM: 600520 MGI: 1933277 HomoloGene: 56331
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2957 83602
Ensembl ENSG00000165417 ENSMUSG00000020962
Uniprot P52655 Q0VGZ0
Refseq NM_015859 (mRNA)
NP_056943 (protein)		 NM_031391 (mRNA)
NP_113568 (protein)
Location Chr 14: 80.72 - 80.76 Mb Chr 12: 91.96 - 92 Mb
Pubmed search [1] [2]

General transcription factor IIA, 1, 19/37kDa, also known as GTF2A1, is a human gene.[1]


[edit] =See also

[edit] References

  1. ^ Entrez Gene: GTF2A1 general transcription factor IIA, 1, 19/37kDa.

[edit] Further reading

  • Ha I, Lane WS, Reinberg D (1991). "Cloning of a human gene encoding the general transcription initiation factor IIB.". Nature 352 (6337): 689-95. doi:10.1038/352689a0. PMID 1876184. 
  • DeJong J, Bernstein R, Roeder RG (1995). "Human general transcription factor TFIIA: characterization of a cDNA encoding the small subunit and requirement for basal and activated transcription.". Proc. Natl. Acad. Sci. U.S.A. 92 (8): 3313-7. PMID 7724559. 
  • Ozer J, Moore PA, Bolden AH, et al. (1994). "Molecular cloning of the small (gamma) subunit of human TFIIA reveals functions critical for activated transcription.". Genes Dev. 8 (19): 2324-35. PMID 7958899. 
  • Sun X, Ma D, Sheldon M, et al. (1994). "Reconstitution of human TFIIA activity from recombinant polypeptides: a role in TFIID-mediated transcription.". Genes Dev. 8 (19): 2336-48. PMID 7958900. 
  • Ge H, Roeder RG (1994). "The high mobility group protein HMG1 can reversibly inhibit class II gene transcription by interaction with the TATA-binding protein.". J. Biol. Chem. 269 (25): 17136-40. PMID 8006019. 
  • DeJong J, Roeder RG (1993). "A single cDNA, hTFIIA/alpha, encodes both the p35 and p19 subunits of human TFIIA.". Genes Dev. 7 (11): 2220-34. PMID 8224848. 
  • Ma D, Watanabe H, Mermelstein F, et al. (1993). "Isolation of a cDNA encoding the largest subunit of TFIIA reveals functions important for activated transcription.". Genes Dev. 7 (11): 2246-57. PMID 8224850. 
  • Tang H, Sun X, Reinberg D, Ebright RH (1996). "Protein-protein interactions in eukaryotic transcription initiation: structure of the preinitiation complex.". Proc. Natl. Acad. Sci. U.S.A. 93 (3): 1119-24. PMID 8577725. 
  • Kashanchi F, Khleif SN, Duvall JF, et al. (1996). "Interaction of human immunodeficiency virus type 1 Tat with a unique site of TFIID inhibits negative cofactor Dr1 and stabilizes the TFIID-TFIIA complex.". J. Virol. 70 (8): 5503-10. PMID 8764062. 
  • Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat.". Science 274 (5287): 605-10. PMID 8849451. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548. 
  • Ozer J, Mitsouras K, Zerby D, et al. (1998). "Transcription factor IIA derepresses TATA-binding protein (TBP)-associated factor inhibition of TBP-DNA binding.". J. Biol. Chem. 273 (23): 14293-300. PMID 9603936. 
  • Yokomori K, Verrijzer CP, Tjian R (1998). "An interplay between TATA box-binding protein and transcription factors IIE and IIA modulates DNA binding and transcription.". Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6722-7. PMID 9618479. 
  • Na SY, Choi HS, Kim JW, et al. (1998). "Bcl3, an IkappaB protein, as a novel transcription coactivator of the retinoid X receptor.". J. Biol. Chem. 273 (47): 30933-8. PMID 9812988. 
  • Upadhyaya AB, Lee SH, DeJong J (1999). "Identification of a general transcription factor TFIIAalpha/beta homolog selectively expressed in testis.". J. Biol. Chem. 274 (25): 18040-8. PMID 10364255. 
  • Kim HJ, Yi JY, Sung HS, et al. (1999). "Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation.". Mol. Cell. Biol. 19 (9): 6323-32. PMID 10454579. 
  • Lee SK, Anzick SL, Choi JE, et al. (1999). "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo.". J. Biol. Chem. 274 (48): 34283-93. PMID 10567404. 
  • Teichmann M, Wang Z, Martinez E, et al. (2000). "Human TATA-binding protein-related factor-2 (hTRF2) stably associates with hTFIIA in HeLa cells.". Proc. Natl. Acad. Sci. U.S.A. 96 (24): 13720-5. PMID 10570139. 
  • Solow S, Salunek M, Ryan R, Lieberman PM (2001). "Taf(II) 250 phosphorylates human transcription factor IIA on serine residues important for TBP binding and transcription activity.". J. Biol. Chem. 276 (19): 15886-92. doi:10.1074/jbc.M009385200. PMID 11278496. 
  • Xing J, Sheppard HM, Corneillie SI, Liu X (2001). "p53 Stimulates TFIID-TFIIA-promoter complex assembly, and p53-T antigen complex inhibits TATA binding protein-TATA interaction.". Mol. Cell. Biol. 21 (11): 3652-61. doi:10.1128/MCB.21.11.3652-3661.2001. PMID 11340159. 
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v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD