Cholesterol 7 alpha-hydroxylase
From Wikipedia, the free encyclopedia
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cytochrome P450, family 7, subfamily A, polypeptide 1
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| Identifiers | |
| Symbol | CYP7A1 |
| Alt. Symbols | CYP7 |
| Entrez | 1581 |
| HUGO | 2651 |
| OMIM | 118455 |
| RefSeq | NM_000780 |
| UniProt | P22680 |
| Other data | |
| EC number | 1.14.13.17 |
| Locus | Chr. 8 q11-q12 |
Cholesterol 7 alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in the synthesis of bile acid from cholesterol, catalyzing the formation of 7-alpha-hydroxycholesterol.
It is downregulated by Sterol regulatory element binding proteins (SREBP) when plasma cholesterol levels are low. It is upregulated by the nuclear receptor LXR (liver X receptor) when cholesterol (specifically - oxysterol) levels are high.[1] The effect of this upregulation is to increase the production of bile acids and reduce the level of cholesterol in hepatocytes.
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