Squalene monooxygenase

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squalene epoxidase
Identifiers
Symbol	SQLE
Entrez	6713
HUGO	11279
OMIM	602019
RefSeq	NM_003129
UniProt	Q14534
Other data
EC number	1.14.99.7
Locus	Chr. 8 q24.1

Squalene monooxygenase (or squalene epoxidase) is an enzyme which uses NADPH to reduce squalene to 2,3-oxidosqualene (squalene epoxide).

[edit] See also

• Antifungal_drug#Allylamines

[edit] External links

• MeSH Squalene+monooxygenase

v • d • e Oxidoreductases: dioxygenases, including steroid hydroxylases (EC 1.14) 1.14.11 - 2-oxoglutarate Prolyl hydroxylase - Lysyl hydroxylase 1.14.13 - NADH or NADPH Flavin-containing monooxygenase - Nitric oxide synthase (NOS1, NOS2A, NOS3) - Cholesterol 7 alpha-hydroxylase - Methane monooxygenase - 3A4 -51A1 1.14.14 - reduced flavin or flavoprotein 19A1 - 2D6 - 2E1 1.14.15 - reduced iron-sulfur protein 11B1 - 11B2 - 11A1 1.14.16 - reduced pteridine Phenylalanine hydroxylase - Tyrosine hydroxylase - Tryptophan hydroxylase 1.14.17 - reduced ascorbate Dopamine beta hydroxylase 1.14.18-19 - other Tyrosinase - Stearoyl-CoA desaturase-1 1.14.99 - miscellaneous Cyclooxygenase - Heme oxygenase (HMOX1) - Squalene monooxygenase - 17A1 - 21A2

v • d • e Metabolism: lipid metabolism - ketones/mevalonate pathway/cholesterol synthesis enzymes To HMG-CoA Acetyl-Coenzyme A acetyltransferase - HMG-CoA synthase (regulated step) Ketogenesis HMG-CoA lyase - 3-hydroxybutyrate dehydrogenase - Thiophorase To Mevalonic acid HMG-CoA reductase To DMAPP Mevalonate kinase - Phosphomevalonate kinase - Pyrophosphomevalonate decarboxylase - Isopentenyl-diphosphate delta isomerase To Cholesterols Dimethylallyltranstransferase - Geranyl pyrophosphate - Farnesyl-diphosphate farnesyltransferase - Squalene monooxygenase - Lanosterol synthase - CYP51A1 To Bile acids Cholesterol 7 alpha-hydroxylase see also intermediates