Phosphomevalonate kinase

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phosphomevalonate kinase
Identifiers
Symbol	PMVK
Entrez	10654
HUGO	9141
OMIM	607622
RefSeq	NM_006556
UniProt	Q15126
Other data
EC number	2.7.4.2
Locus	Chr. 1 p13-q23

Phosphomevalonate kinase is an enzyme in the mevalonate pathway.

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• MeSH Phosphomevalonate+kinase

v • d • e Transferases: Phosphotransferases/kinases (EC 2.7) 2.7.1 - OH acceptor Hexo- - Gluco- - Fructo- (Hepatic fructo-) - Galacto- - Phosphofructo- (1, 2) - Riboflavin - Shikimate - Thymidine - NAD+ - Glycerol - Pantothenate - Mevalonate - Pyruvate - Deoxycytidine - PFP - Diacylglycerol - Bruton's tyrosine - Phosphoinositide 3 (Class I PI 3, Class II PI 3) - Sphingosine 2.7.2 - COOH acceptor Phosphoglycerate - Aspartate 2.7.3 - N acceptor Creatine 2.7.4 - PO4 acceptor Phosphomevalonate - Adenylate - Nucleoside-diphosphate 2.7.6 - P2O7 Ribose-phosphate diphosphokinase - Thiamine pyrophosphokinase 2.7.7 - nucleotidyl- Integrase - PNPase - Polymerase - RNase PH - UDP-glucose pyrophosphorylase - Galactose-1-phosphate uridylyltransferase -Terminal deoxynucleotidyl transferase - RNA replicase - Reverse transcriptase (Telomerase) - Transposase 2.7.8 - other phos. N-acetylglucosamine-1-phosphate transferase 2.7.10-11 - protein Tyrosine - Serine/threonine-specific

v • d • e Metabolism: lipid metabolism - ketones/mevalonate pathway/cholesterol synthesis enzymes To HMG-CoA Acetyl-Coenzyme A acetyltransferase - HMG-CoA synthase (regulated step) Ketogenesis HMG-CoA lyase - 3-hydroxybutyrate dehydrogenase - Thiophorase To Mevalonic acid HMG-CoA reductase To DMAPP Mevalonate kinase - Phosphomevalonate kinase - Pyrophosphomevalonate decarboxylase - Isopentenyl-diphosphate delta isomerase To Cholesterols Dimethylallyltranstransferase - Geranyl pyrophosphate - Farnesyl-diphosphate farnesyltransferase - Squalene monooxygenase - Lanosterol synthase - CYP51A1 To Bile acids Cholesterol 7 alpha-hydroxylase see also intermediates