Acetyl-Coenzyme A acetyltransferase

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acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase)
Identifiers
Symbol	ACAT1
Alt. Symbols	ACAT
Entrez	38
HUGO	93
OMIM	607809
RefSeq	NM_000019
UniProt	P24752
Other data
EC number	2.3.1.9
Locus	Chr. 11 q22.3-23.1

acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase)
Identifiers
Symbol	ACAT2
Entrez	39
HUGO	94
OMIM	100678
RefSeq	NM_005891
UniProt	Q9BWD1
Other data
EC number	2.3.1.9
Locus	Chr. 6 q25.3-q26

Acetyl-Coenzyme A acetyltransferase (or thiolase) is an enzyme which converts two units of acetyl-CoA to acetoacetyl CoA in the mevalonate pathway.

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• MeSH Acetyl-CoA+C-Acetyltransferase

v • d • e Transferases: acyltransferases (EC 2.3) 2.3.1: other than amino-acyl groups (mostly acetyltransferases) N-Acetylglutamate synthase - Choline acetyltransferase - Acetyl-Coenzyme A acetyltransferase - Dihydrolipoyl transacetylase - Acetyl-CoA C-acyltransferase - Beta-galactoside transacetylase - Carnitine O-palmitoyltransferase (CPT1, CPT2) - Acyltransferase like 2 - Chloramphenicol acetyltransferase - Aminolevulinic acid synthase - Beta-ketoacyl-ACP synthase - Glyceronephosphate O-acyltransferase - Lecithin-cholesterol acyltransferase - Histone acetyltransferase (P300/CBP) - Serotonin N-acetyl transferase - Serine C-palmitoyltransferase (SPTLC1, SPTLC2) - HGSNAT 2.3.2 - Aminoacyltransferases Gamma-glutamyl transpeptidase - Peptidyl transferase - Transglutaminase (Tissue transglutaminase, Keratinocyte transglutaminase, Factor XIII) 2.3.3 - converted into alkyl on transfer Citrate synthase - ATP citrate lyase - HMG-CoA synthase

v • d • e Metabolism: lipid metabolism - ketones/mevalonate pathway/cholesterol synthesis enzymes To HMG-CoA Acetyl-Coenzyme A acetyltransferase - HMG-CoA synthase (regulated step) Ketogenesis HMG-CoA lyase - 3-hydroxybutyrate dehydrogenase - Thiophorase To Mevalonic acid HMG-CoA reductase To DMAPP Mevalonate kinase - Phosphomevalonate kinase - Pyrophosphomevalonate decarboxylase - Isopentenyl-diphosphate delta isomerase To Cholesterols Dimethylallyltranstransferase - Geranyl pyrophosphate - Farnesyl-diphosphate farnesyltransferase - Squalene monooxygenase - Lanosterol synthase - CYP51A1 To Bile acids Cholesterol 7 alpha-hydroxylase see also intermediates