Lanosterol synthase

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lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
Identifiers
Symbol	LSS
Entrez	4047
HUGO	6708
OMIM	600909
RefSeq	NM_002340
UniProt	P48449
Other data
EC number	5.4.99.7
Locus	Chr. 21 q22.3

Lanosterol synthase is an enzyme which converts 2,3-oxidosqualene to a protosterol cation and finally to lanosterol.

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• MeSH Lanosterol+synthase

v • d • e Isomerase: mutases (EC 5.4) 5.4.2 Phosphomutases Phosphoglycerate mutase - Bisphosphoglycerate mutase - Phosphoglucomutase 5.4.99 Other groups Methylmalonyl-CoA mutase - Lanosterol synthase

v • d • e Metabolism: lipid metabolism - ketones/mevalonate pathway/cholesterol synthesis enzymes To HMG-CoA Acetyl-Coenzyme A acetyltransferase - HMG-CoA synthase (regulated step) Ketogenesis HMG-CoA lyase - 3-hydroxybutyrate dehydrogenase - Thiophorase To Mevalonic acid HMG-CoA reductase To DMAPP Mevalonate kinase - Phosphomevalonate kinase - Pyrophosphomevalonate decarboxylase - Isopentenyl-diphosphate delta isomerase To Cholesterols Dimethylallyltranstransferase - Geranyl pyrophosphate - Farnesyl-diphosphate farnesyltransferase - Squalene monooxygenase - Lanosterol synthase - CYP51A1 To Bile acids Cholesterol 7 alpha-hydroxylase see also intermediates