Dimethylallyltranstransferase

farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)
Identifiers
Symbol	FDPS
Entrez	2224
HUGO	3631
OMIM	134629
RefSeq	NM_002004
UniProt	P14324
Other data
EC number	2.5.1.1
Locus	Chr. 1 q22

Dimethylallyltranstransferase is an enzyme which converts dimethylallylpyrophosphate and isopentenyl pyrophosphate into farnesylpyrophosphate. It is also commonly referred to as farnesylpyrophosphate synthase or farnesyldiphosphate synthase.

Pyrophosphate is also involved, both as a reactant and product. Geranylpyrophosphate is created in an intermediate step.

[edit] See also

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v • d • e Alkyl and aryl transferases (EC 2.5)

Dimethylallyltranstransferase - Thiaminase I - Methionine adenosyltransferase - Riboflavin synthase - Dihydropteroate synthetase - Spermidine synthase - Glutathione S-transferase - Farnesyl-diphosphate farnesyltransferase - Spermine synthase - Alkylglycerone phosphate synthase - Farnesyltransferase - Geranylgeranyltransferase type 1 - Porphobilinogen deaminase

v • d • e Metabolism: lipid metabolism - ketones/mevalonate pathway/cholesterol synthesis enzymes

To HMG-CoA	Acetyl-Coenzyme A acetyltransferase - HMG-CoA synthase (regulated step)

Ketogenesis	HMG-CoA lyase - 3-hydroxybutyrate dehydrogenase - Thiophorase

To Mevalonic acid	HMG-CoA reductase

To DMAPP	Mevalonate kinase - Phosphomevalonate kinase - Pyrophosphomevalonate decarboxylase - Isopentenyl-diphosphate delta isomerase

To Cholesterols	Dimethylallyltranstransferase - Geranyl pyrophosphate - Farnesyl-diphosphate farnesyltransferase - Squalene monooxygenase - Lanosterol synthase - CYP51A1

To Bile acids	Cholesterol 7 alpha-hydroxylase

see also intermediates