Geranyltranstransferase

From Wikipedia, the free encyclopedia

In enzymology, a geranyltranstransferase (EC 2.5.1.10) is an enzyme that catalyzes the chemical reaction

geranyl diphosphate + isopentenyl diphosphate $\rightleftharpoons$ diphosphate + trans,trans-farnesyl diphosphate

Thus, the two substrates of this enzyme are geranyl diphosphate and isopentenyl diphosphate, whereas its two products are diphosphate and trans,trans-farnesyl diphosphate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase. Other names in common use include farnesyl-diphosphate synthase, geranyl transferase I, prenyltransferase, farnesyl pyrophosphate synthetase, and farnesylpyrophosphate synthetase. This enzyme participates in biosynthesis of steroids and terpenoid biosynthesis.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 25 structures have been solved for this class of enzymes, with PDB accession codes 1FPS, 1RQI, 1RQJ, 1YHK, 1YHM, 1YQ7, 1YV5, 1ZW5, 2EWG, 2F7M, 2F89, 2F8C, 2F8Z, 2F92, 2F94, 2F9K, 2FOR, 2FTZ, 2H8O, 2I19, 2OGD, 2OPN, 2Q80, 2QIS, and 2RAH.

[edit] References

IUBMB entry for 2.5.1.10
BRENDA references for 2.5.1.10 (Recommended.)
PubMed references for 2.5.1.10
PubMed Central references for 2.5.1.10
Google Scholar references for 2.5.1.10
EM (1959). "Zur Biosynthese der Terpene. VI gamma,gamma-Dimethyl-allyl-pyrophosphat und Geranyl-pyrophosphat, biologische Vorstufen des Squalens". Angew. Chem. 71: 657–663. doi:10.1002/ange.19590712102.
Ogura K, Nishino T, Seto S (Tokyo). "The purification of prenyltransferase and isopentenyl pyrophosphate isomerase of pumpkin fruit and their some properties". J. Biochem.: 197–203. PMID 4303505.
Reed BC, Rilling HC (1975). "Crystallization and partial characterization of prenyltransferase from avian liver". Biochemistry. 14: 50–4. doi:10.1021/bi00672a009. PMID 1109590.
Takahashi I, Ogura K (Tokyo). "Farnesyl pyrophosphate synthetase from Bacillus subtilis". J. Biochem.: 1581–7. PMID 6792191.
Takahashi I, Ogura K (Tokyo). "Prenyltransferases of Bacillus subtilis: undecaprenyl pyrophosphate synthetase and geranylgeranyl pyrophosphate synthetase". J. Biochem.: 1527–37. PMID 6818223.