Methionine adenosyltransferase

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methionine adenosyltransferase I, alpha
Identifiers
Symbol	MAT1A
Entrez	4143
HUGO	6903
OMIM	250850
RefSeq	NM_000429
UniProt	Q00266
Other data
Locus	Chr. 10 q22

methionine adenosyltransferase II, alpha
Identifiers
Symbol	MAT2A
Entrez	4144
HUGO	6904
OMIM	601468
RefSeq	NM_005911
UniProt	P31153
Other data
Locus	Chr. 2 p11.2

methionine adenosyltransferase II, beta
Identifiers
Symbol	MAT2B
Entrez	27430
HUGO	6905
OMIM	605527
RefSeq	NM_013283
UniProt	Q9NZL9
Other data
Locus	Chr. 5 q34-q35

Methionine adenosyltransferase is an enzyme which catalyses the synthesis of S-adenosylmethionine (SAM) from methionine and ATP.

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• MeSH Methionine+adenosyltransferase
• EC 2.5.1.6

v • d • e Alkyl and aryl transferases (EC 2.5) Dimethylallyltranstransferase - Thiaminase I - Methionine adenosyltransferase - Riboflavin synthase - Dihydropteroate synthetase - Spermidine synthase - Glutathione S-transferase - Farnesyl-diphosphate farnesyltransferase - Spermine synthase - Alkylglycerone phosphate synthase - Farnesyltransferase - Geranylgeranyltransferase type 1 - Porphobilinogen deaminase

v • d • e Metabolism: amino acid metabolism - synthesis and catabolism enzymes (essential in CAPS) K→acetyl-CoA LYSINE→ Saccharopine dehydrogenase - Glutaryl-CoA dehydrogenase LEUCINE→ Branched chain aminotransferase - Branched-chain alpha-keto acid dehydrogenase complex - Isovaleryl coenzyme A dehydrogenase - Methylcrotonyl-CoA carboxylase - Methylglutaconyl-CoA hydratase - 3-hydroxy-3-methylglutaryl-CoA lyase TRYPTOPHAN→ Indoleamine 2,3-dioxygenase/Tryptophan 2,3-dioxygenase - Arylformamidase - Kynureninase - 3-hydroxyanthranilate oxidase - Aminocarboxymuconate-semialdehyde decarboxylase - Aminomuconate-semialdehyde dehydrogenase PHENYLALANINE→tyrosine→ (see below) G→pyruvate glycine→serine→ Serine hydroxymethyltransferase - Serine dehydratase alanine→ Alanine transaminase cysteine→ D-cysteine desulfhydrase threonine→ L-threonine dehydrogenase G→glutamate HISTIDINE→ Histidine ammonia-lyase - Urocanate hydratase - Formiminotransferase cyclodeaminase proline→ Proline oxidase - Pyrroline-5-carboxylate reductase - 1-Pyrroline-5-carboxylate dehydrogenase/ALDH4A1 - PYCR1 arginine→ Ornithine aminotransferase - Ornithine decarboxylase - Agmatinase →alpha-ketoglutarate→TCA Glutamate dehydrogenase G→propionyl-CoA VALINE→ Branched chain aminotransferase - Branched-chain alpha-keto acid dehydrogenase complex - Enoyl-CoA hydratase - 3-hydroxyisobutyryl-CoA hydrolase - 3-hydroxyisobutyrate dehydrogenase - Methylmalonate semialdehyde dehydrogenase ISOLEUCINE→ Branched chain aminotransferase - Branched-chain alpha-keto acid dehydrogenase complex - 3-hydroxy-2-methylbutyryl-CoA dehydrogenase METHIONINE→ Methionine adenosyltransferase - Adenosylhomocysteinase - Cystathionine beta synthase - Cystathionine gamma-lyase (methionine synthesis: MTR/Homocysteine methyltransferase) THREONINE→ Threonine aldolase →succinyl-CoA→TCA Propionyl-CoA carboxylase - Methylmalonyl-CoA mutase G→fumarate PHENYLALANINE→tyrosine→ Phenylalanine hydroxylase - Tyrosine aminotransferase - 4-Hydroxyphenylpyruvate dioxygenase - Homogentisate 1,2-dioxygenase - Fumarylacetoacetate hydrolase G→oxaloacetate asparagine→aspartate→ Asparaginase/Asparagine synthetase - Aspartate transaminase Other tyrosine→melanin Tyrosinase cysteine+glutamate→glutathione Gamma-glutamylcysteine synthetase - Glutathione synthetase glycine→creatine Guanidinoacetate N-methyltransferase - Creatine kinase glutamate→glutamine Glutamine synthetase - Glutaminase proline+lysine→collagen Prolyl hydroxylase - Lysyl hydroxylase see also disorders, intermediates