Agmatinase

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In enzymology, an agmatinase (EC 3.5.3.11) is an enzyme that catalyzes the chemical reaction

agmatine + H2O \rightleftharpoons putrescine + urea

Thus, the two substrates of this enzyme are agmatine and H2O, whereas its two products are putrescine and urea.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is agmatine amidinohydrolase. Other names in common use include agmatine ureohydrolase, and SpeB. This enzyme participates in urea cycle and metabolism of amino groups.

Contents

[edit] Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1GQ6, 1GQ7, 1WOG, 1WOH, and 1WOI.

[edit] References

[edit] External links

The CAS registry number for this enzyme class is 37289-16-0.

[edit] Gene Ontology (GO) codes

v • d • e
Carbon-nitrogen non-peptide hydrolases (EC 3.5)
3.5.1 - Amidohydrolases
3.5.2
3.5.3
Arginase - Agmatinase
3.5.4 - Aminohydrolases
Other
v • d • e
Metabolism: amino acid metabolism - synthesis and catabolism enzymes (essential in CAPS)
K→acetyl-CoA
(see below)
G→pyruvate
G→glutamate
G→propionyl-CoA
→succinyl-CoA→TCA
G→fumarate
G→oxaloacetate
Other
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