3-hydroxy-2-methylbutyryl-CoA dehydrogenase
From Wikipedia, the free encyclopedia
In enzymology, a 3-hydroxy-2-methylbutyryl-CoA dehydrogenase (EC 1.1.1.178) is an enzyme that catalyzes the chemical reaction
- (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD+
2-methylacetoacetyl-CoA + NADH + H+
Thus, the two substrates of this enzyme are (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA and NAD+, whereas its 3 products are 2-methylacetoacetyl-CoA, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase. Other names in common use include 2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase, 2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase, and 2-methyl-3-hydroxy-butyryl CoA dehydrogenase. This enzyme participates in valine, leucine and isoleucine degradation.
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[edit] Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2O23.
[edit] References
- IUBMB entry for 1.1.1.178
- BRENDA references for 1.1.1.178 (Recommended.)
- PubMed references for 1.1.1.178
- PubMed Central references for 1.1.1.178
- Google Scholar references for 1.1.1.178
- Conrad RS, Massey LK, Sokatch JR (1974). "D- and L-isoleucine metabolism and regulation of their pathways in Pseudomonas putida". J. Bacteriol. 118: 103–11. PMID 4150713.
[edit] External links
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- The CAS registry number for this enzyme class is 52227-66-4.
[edit] Gene Ontology (GO) codes
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