3-hydroxyisobutyrate dehydrogenase
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In enzymology, a 3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31) is an enzyme that catalyzes the chemical reaction
- 3-hydroxy-2-methylpropanoate + NAD+
2-methyl-3-oxopropanoate + NADH + H+
Thus, the two substrates of this enzyme are 3-hydroxy-2-methylpropanoate and NAD+, whereas its 3 products are 2-methyl-3-oxopropanoate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-hydroxy-2-methylpropanoate:NAD+ oxidoreductase. This enzyme is also called beta-hydroxyisobutyrate dehydrogenase. This enzyme participates in valine, leucine and isoleucine degradation.
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[edit] Structural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1WP4, 2CVZ, 2GF2, 2H78, and 2I9P.
[edit] References
- IUBMB entry for 1.1.1.31
- BRENDA references for 1.1.1.31 (Recommended.)
- PubMed references for 1.1.1.31
- PubMed Central references for 1.1.1.31
- Google Scholar references for 1.1.1.31
- Robinson WG and Coon MJ (1957). "Purification and properties of beta-hydroxyisobutyric dehydrogenase". J. Biol. Chem. 225: 511–521.
[edit] External links
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- The CAS registry number for this enzyme class is 9028-39-1.
[edit] Gene Ontology (GO) codes
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