PYCR1
From Wikipedia, the free encyclopedia
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Pyrroline-5-carboxylate reductase 1
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| PDB rendering based on 2ger. | |||||||||||
| Available structures: 2ger, 2gr9, 2gra, 2izz | |||||||||||
| Identifiers | |||||||||||
| Symbol(s) | PYCR1; P5C; P5CR; PIG45; PP222; PYCR | ||||||||||
| External IDs | OMIM: 179035 MGI: 2384795 HomoloGene: 56002 | ||||||||||
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| RNA expression pattern | |||||||||||
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| Orthologs | |||||||||||
| Human | Mouse | ||||||||||
| Entrez | 5831 | 209027 | |||||||||
| Ensembl | ENSG00000183010 | ENSMUSG00000025140 | |||||||||
| Uniprot | P32322 | Q3UTR5 | |||||||||
| Refseq | NM_006907 (mRNA) NP_008838 (protein) |
NM_144795 (mRNA) NP_659044 (protein) |
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| Location | Chr 17: 77.48 - 77.49 Mb | Chr 11: 120.46 - 120.46 Mb | |||||||||
| Pubmed search | [1] | [2] | |||||||||
Pyrroline-5-carboxylate reductase 1, also known as PYCR1, is a human gene.[1]
This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternate splicing results in two transcript variants encoding different isoforms.[1]
[edit] References
[edit] Further reading
- Herzfeld A, Legg MA, Greengard O (1978). "Human colon tumors: enzymic and histological characteristics.". Cancer 42 (3): 1280-3. PMID 212173.
- Dougherty KM, Brandriss MC, Valle D (1992). "Cloning human pyrroline-5-carboxylate reductase cDNA by complementation in Saccharomyces cerevisiae.". J. Biol. Chem. 267 (2): 871-5. PMID 1730675.
- Merrill MJ, Yeh GC, Phang JM (1989). "Purified human erythrocyte pyrroline-5-carboxylate reductase. Preferential oxidation of NADPH.". J. Biol. Chem. 264 (16): 9352-8. PMID 2722838.
- Yeh GC, Roth EF, Phang JM, et al. (1984). "The effect of pyrroline-5-carboxylic acid on nucleotide metabolism in erythrocytes from normal and glucose-6-phosphate dehydrogenase-deficient subjects.". J. Biol. Chem. 259 (9): 5454-8. PMID 6201483.
- Herzfeld A, Greengard O (1981). "Enzyme activities in human fetal and neoplastic tissues.". Cancer 46 (9): 2047-54. PMID 6253048.
- Yeh GC, Harris SC, Phang JM (1981). "Pyrroline-5-carboxylate reductase in human erythrocytes.". J. Clin. Invest. 67 (4): 1042-6. PMID 6894153.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
- Basch JJ, Wickham ED, Farrell HM (1997). "Pyrroline-5-carboxylate reductase in lactating bovine mammary glands.". J. Dairy Sci. 79 (8): 1361-8. PMID 8880459.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:. PMID 15489334.
- Meng Z, Lou Z, Liu Z, et al. (2006). "Crystal structure of human pyrroline-5-carboxylate reductase.". J. Mol. Biol. 359 (5): 1364-77. doi:. PMID 16730026.
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