Hepatic fructokinase

ketohexokinase (fructokinase)
Identifiers
Symbol	KHK
Entrez	3795
HUGO	6315
OMIM	229800
RefSeq	NM_006488
UniProt	P50053
Other data
EC number	2.7.1.3
Locus	Chr. 2 p23.3-23.2

Hepatic fructokinase (or ketohexokinase ) is an enzyme that catalyzes the phosphorylation of fructose to produce fructose-1-phosphate.

ATP + D-fructose → ADP + D-fructose-1-phosphate^[1]

[edit] Pathology

A deficiency is associated with essential fructosuria.

^ Bais R, James HM, Rofe AM, Conyers RA (1985). "The purification and properties of human liver ketohexokinase. A role for ketohexokinase and fructose-bisphosphate aldolase in the metabolic production of oxalate from xylitol". Biochem. J. 230 (1): 53–60. PMID 2996495.

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v • d • e Transferases: Phosphotransferases/kinases (EC 2.7)

2.7.1 - OH acceptor	Hexo- - Gluco- - Fructo- (Hepatic fructo-) - Galacto- - Phosphofructo- (1, 2) - Riboflavin - Shikimate - Thymidine - NAD⁺ - Glycerol - Pantothenate - Mevalonate - Pyruvate - Deoxycytidine - PFP - Diacylglycerol - Bruton's tyrosine - Phosphoinositide 3 (Class I PI 3, Class II PI 3) - Sphingosine

2.7.2 - COOH acceptor	Phosphoglycerate - Aspartate

2.7.3 - N acceptor	Creatine

2.7.4 - PO₄ acceptor	Phosphomevalonate - Adenylate - Nucleoside-diphosphate

2.7.6 - P₂O₇	Ribose-phosphate diphosphokinase - Thiamine pyrophosphokinase

2.7.7 - nucleotidyl-	Integrase - PNPase - Polymerase - RNase PH - UDP-glucose pyrophosphorylase - Galactose-1-phosphate uridylyltransferase -Terminal deoxynucleotidyl transferase - RNA replicase - Reverse transcriptase (Telomerase) - Transposase

2.7.8 - other phos.	N-acetylglucosamine-1-phosphate transferase

2.7.10-11 - protein	Tyrosine - Serine/threonine-specific

v • d • e Metabolism: carbohydrate metabolism - fructose and galactose enzymes

Fructose	Hepatic fructokinase - Aldolase B

Sorbitol	Sorbitol dehydrogenase - Aldose reductase

Galactose	Galactokinase - Galactose-1-phosphate uridylyltransferase - UDP galactose epimerase Aldose reductase

Lactose	Lactose synthase - Lactase

see also disorders