25-Hydroxyvitamin D3 1-alpha-hydroxylase

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cytochrome P450, family 27, subfamily B, polypeptide 1
Identifiers
Symbol	CYP27B1
Alt. Symbols	VDD1, PDDR
Entrez	1594
HUGO	2606
OMIM	609506
RefSeq	NM_000785
UniProt	O15528
Other data
Locus	Chr. 12 q13.3-q14

25-Hydroxyvitamin D3 1-alpha-Hydroxylase is a cytochrome P450 enzyme in the proximal tubule which converts calcidiol to calcitriol (the bioactive form of Vitamin D).

Calcidiol

Calcitriol

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• MeSH 25-Hydroxyvitamin+D3+1-alpha-Hydroxylase

v • d • e Cytochromes, oxygenases: cytochrome P450 (EC 1.14) CYP1 A1, A2, B1 CYP2 A6, A7, A13, B6, C8, C9, C18, C19, D6, E1, F1, J2, R1, S1, U1, W1 CYP3 A4, A5, A7, A43 CYP4 A11, A22, B1, F2, F3, F8, F11, F12, F22, V2, X1, Z1 CYP5-20 CYP5 (A1) - CYP7 (A1, B1) - CYP8 (A1, B1) - CYP11 (A1, B1, B2) - CYP17 (A1) - CYP19 (A1) - CYP20 (A1) CYP21-51 CYP21 (A2) - CYP24 (A1) - CYP26 (A1, B1, C1) - CYP27 (A1, B1, C1) - CYP39 (A1) - CYP46 (A1) - CYP51 (A1)

v • d • e Metabolism of vitamins, coenzymes, and cofactors Vitamin A Retinol binding protein Thiamine (B1) Thiamine pyrophosphokinase Niacin (B3) Indoleamine 2,3-dioxygenase - Formamidase Folic acid (B9) Dihydropteroate synthetase - Dihydrofolate reductase - Serine hydroxymethyltransferase Vitamin C L-gulonolactone oxidase Vitamin D 25-Hydroxyvitamin D3 1-alpha-hydroxylase - CYP27A1 Vitamin K Vitamin K epoxide reductase