CYP3A43

From Wikipedia, the free encyclopedia

Cytochrome P450, family 3, subfamily A, polypeptide 43

Identifiers

CYP3A43; MGC119315; MGC119316

External IDs

OMIM: 606534 MGI: 1930638 HomoloGene: 75118

Gene ontology
Molecular Function:	• monooxygenase activity • iron ion binding • heme binding • metal ion binding • unspecific monooxygenase activity
Cellular Component:	• membrane fraction • endoplasmic reticulum • microsome • membrane
Biological Process:	• electron transport • xenobiotic metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_022820 (mRNA)
NP_073731 (protein)

XM_001004890 (mRNA)
XP_001004890 (protein)

Location

Chr 7: 99.26 - 99.3 Mb

Chr 5: 146.28 - 146.31 Mb

Pubmed search

[1]

[2]

Cytochrome P450, family 3, subfamily A, polypeptide 43, also known as CYP3A43, is a human gene.^[1]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme has a low level of testosterone hydroxylase activity. Although it bears homology to some drug-metabolizing cytochrome P450s, it is unknown whether the enzyme is also involved in xenobiotic metabolism. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing of this gene results in three transcript variants encoding different isoforms.^[1]

[edit] References

^ ^a ^b Entrez Gene: CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43.

[edit] Further reading

Smith G, Stubbins MJ, Harries LW, Wolf CR (1999). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily.". Xenobiotica 28 (12): 1129-65. PMID 9890157.
Finta C, Zaphiropoulos PG (2001). "The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons.". Gene 260 (1-2): 13-23. PMID 11137287.
Domanski TL, Finta C, Halpert JR, Zaphiropoulos PG (2001). "cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450.". Mol. Pharmacol. 59 (2): 386-92. PMID 11160876.
Westlind A, Malmebo S, Johansson I, et al. (2001). "Cloning and tissue distribution of a novel human cytochrome p450 of the CYP3A subfamily, CYP3A43.". Biochem. Biophys. Res. Commun. 281 (5): 1349-55. doi:10.1006/bbrc.2001.4505. PMID 11243885.
Gellner K, Eiselt R, Hustert E, et al. (2001). "Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene.". Pharmacogenetics 11 (2): 111-21. PMID 11266076.
Finta C, Zaphiropoulos PG (2002). "Intergenic mRNA molecules resulting from trans-splicing.". J. Biol. Chem. 277 (8): 5882-90. doi:10.1074/jbc.M109175200. PMID 11726664.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157-64. doi:10.1038/nature01782. PMID 12853948.
Cauffiez C, Lo-Guidice JM, Chevalier D, et al. (2004). "First report of a genetic polymorphism of the cytochrome P450 3A43 (CYP3A43) gene: identification of a loss-of-function variant.". Hum. Mutat. 23 (1): 101. doi:10.1002/humu.9211. PMID 14695544.
Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance.". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMID 14759258.
Stone A, Ratnasinghe LD, Emerson GL, et al. (2005). "CYP3A43 Pro(340)Ala polymorphism and prostate cancer risk in African Americans and Caucasians.". Cancer Epidemiol. Biomarkers Prev. 14 (5): 1257-61. doi:10.1158/1055-9965.EPI-04-0534. PMID 15894682.
Thompson EE, Kuttab-Boulos H, Yang L, et al. (2006). "Sequence diversity and haplotype structure at the human CYP3A cluster.". Pharmacogenomics J. 6 (2): 105-14. doi:10.1038/sj.tpj.6500347. PMID 16314882.
Shchepotina EG, Nikishina MV, Vavilin VA, Lyakhovich VV (2006). "Analysis of restriction fragment length polymorphism of cytochrome P450 3A43 gene and evaluation of the incidence of CYP3A43*1B allele in europeoid residents of West Siberia.". Bull. Exp. Biol. Med. 140 (6): 726-8. PMID 16848237.