CYP2B6

From Wikipedia, the free encyclopedia

cytochrome P450, family 2, subfamily B, polypeptide 6
Identifiers
Symbol	CYP2B6
Entrez	1555
HUGO	2615
OMIM	123930
RefSeq	NM_000767
UniProt	P20813
Other data
Locus	Chr. 19 q13.2

CYP2B6 is a member of the Cytochrome P450 group of enzymes. Along with CYP2A6, it is involved with metabolizing nicotine, along with many other substances.

[edit] CYP2B6 Ligands

Substrates	Inhibitors	Inducers
Often mentioned [1]: Bupropion (antidepressant) Cyclophosphamide (Alkylating antineoplastic agent) Efavirenz (NNRTI) Ifosfamide (Alkylating antineoplastic agent) Other: Alfentanil (opioid analgesic) Nevirapine (NNRTI) Propofol (anesthetic) tamoxifen (SERM) Valproic acid (anticonvulsant , mood-stabilizing) Artemisinin (against malaria) Pethidine (analgesic) Nicotine (stimulant) Sertraline (SSRI) thiotepa (Alkylating antineoplastic agent)	Strong [2]: Orphenadrine (analgesic) unspecified: Paroxetine (SSRI) fluoxetine (SSRI) Estradiol (sex hormone) Phencyclidine (dissociative) ritonavir (antiretroviral) sertraline (SSRI) thiotepa (Alkylating antineoplastic agent) ticlopidine (antiplatelet)	Often mentioned [1]: carbamazepine (anticonvulsant, mood stabilizer) rifampicin (bactericidal) Other: artemisinin (against malaria) clotrimazole (antifungal) ifosfamide (Alkylating antineoplastic agent) glucocorticoids (antiinflammatory) phenobarbital (anticonvulsant ) phenytoin (antiepileptic) ritonavir (antiretroviral)

[edit] References

1. ^ ^{a b} Mentioned both in the reference named FASS and were previously mentioned in Wikipedia. Further contributions may follow other systems
2. ^ Swedish environmental classification of pharmaceuticals Facts for prescribers (Fakta för förskrivare)

[edit] External links

• MeSH CYP2B6

v • d • e Cytochromes, oxygenases: cytochrome P450 (EC 1.14) CYP1 A1, A2, B1 CYP2 A6, A7, A13, B6, C8, C9, C18, C19, D6, E1, F1, J2, R1, S1, U1, W1 CYP3 A4, A5, A7, A43 CYP4 A11, A22, B1, F2, F3, F8, F11, F12, F22, V2, X1, Z1 CYP5-20 CYP5 (A1) - CYP7 (A1, B1) - CYP8 (A1, B1) - CYP11 (A1, B1, B2) - CYP17 (A1) - CYP19 (A1) - CYP20 (A1) CYP21-51 CYP21 (A2) - CYP24 (A1) - CYP26 (A1, B1, C1) - CYP27 (A1, B1, C1) - CYP39 (A1) - CYP46 (A1) - CYP51 (A1)