Cholecystokinin B receptor

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Cholecystokinin B receptor
PDB rendering based on 1l4t.
Available structures: 1l4t
Identifiers
Symbol(s) CCKBR; CCK-B; GASR
External IDs OMIM: 118445 MGI: 99479 HomoloGene: 7258
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 887 12426
Ensembl ENSG00000110148 ENSMUSG00000030898
Uniprot P32239 Q3ZB46
Refseq NM_176875 (mRNA)
NP_795344 (protein)		 NM_007627 (mRNA)
NP_031653 (protein)
Location Chr 11: 6.24 - 6.25 Mb Chr 7: 105.3 - 105.34 Mb
Pubmed search [1] [2]

Cholecystokinin B receptor, also known as CCKBR, is a human gene.

This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors.[1]

[edit] See also

[edit] References

  1. ^ Entrez Gene: CCKBR cholecystokinin B receptor.

[edit] Further reading

  • Herget T, Sethi T, Wu SV, et al. (1994). "Cholecystokinin stimulates Ca2+ mobilization and clonal growth in small cell lung cancer through CCKA and CCKB/gastrin receptors.". Ann. N. Y. Acad. Sci. 713: 283-97. PMID 8185170. 
  • Pisegna JR, de Weerth A, Huppi K, Wank SA (1992). "Molecular cloning of the human brain and gastric cholecystokinin receptor: structure, functional expression and chromosomal localization.". Biochem. Biophys. Res. Commun. 189 (1): 296-303. PMID 1280419. 
  • Lee YM, Beinborn M, McBride EW, et al. (1993). "The human brain cholecystokinin-B/gastrin receptor. Cloning and characterization.". J. Biol. Chem. 268 (11): 8164-9. PMID 7681836. 
  • Ito M, Iwata N, Taniguchi T, et al. (1995). "Functional characterization of two cholecystokinin-B/gastrin receptor isoforms: a preferential splice donor site in the human receptor gene.". Cell Growth Differ. 5 (10): 1127-35. PMID 7848914. 
  • Miyake A (1995). "A truncated isoform of human CCK-B/gastrin receptor generated by alternative usage of a novel exon.". Biochem. Biophys. Res. Commun. 208 (1): 230-7. doi:10.1006/bbrc.1995.1328. PMID 7887934. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298. 
  • Zimonjic DB, Popescu NC, Matsui T, et al. (1993). "Localization of the human cholecystokinin-B/gastrin receptor gene (CCKBR) to chromosome 11p15.5-->p15.4 by fluorescence in situ hybridization.". Cytogenet. Cell Genet. 65 (3): 184-5. PMID 8222757. 
  • de Weerth A, Pisegna JR, Huppi K, Wank SA (1993). "Molecular cloning, functional expression and chromosomal localization of the human cholecystokinin type A receptor.". Biochem. Biophys. Res. Commun. 194 (2): 811-8. PMID 8343165. 
  • Ito M, Matsui T, Taniguchi T, et al. (1993). "Functional characterization of a human brain cholecystokinin-B receptor. A trophic effect of cholecystokinin and gastrin.". J. Biol. Chem. 268 (24): 18300-5. PMID 8349705. 
  • Song I, Brown DR, Wiltshire RN, et al. (1993). "The human gastrin/cholecystokinin type B receptor gene: alternative splice donor site in exon 4 generates two variant mRNAs.". Proc. Natl. Acad. Sci. U.S.A. 90 (19): 9085-9. PMID 8415658. 
  • Beinborn M, Lee YM, McBride EW, et al. (1993). "A single amino acid of the cholecystokinin-B/gastrin receptor determines specificity for non-peptide antagonists.". Nature 362 (6418): 348-50. doi:10.1038/362348a0. PMID 8455720. 
  • Silvente-Poirot S, Wank SA (1996). "A segment of five amino acids in the second extracellular loop of the cholecystokinin-B receptor is essential for selectivity of the peptide agonist gastrin.". J. Biol. Chem. 271 (25): 14698-706. PMID 8663021. 
  • Tarasova NI, Wank SA, Hudson EA, et al. (1997). "Endocytosis of gastrin in cancer cells expressing gastrin/CCK-B receptor.". Cell Tissue Res. 287 (2): 325-33. PMID 8995203. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149. 
  • O'Briant KC, Ali SY, Weier HU, Bepler G (1999). "An 84-kilobase physical map and repeat polymorphisms of the gastrin/cholecystokinin brain receptor region at the junction of chromosome segments 11p15.4 and 15.5.". Chromosome Res. 6 (5): 415-8. PMID 9872672. 
  • Monstein HJ, Nilsson I, Ellnebo-Svedlund K, Svensson SP (1999). "Cloning and characterization of 5'-end alternatively spliced human cholecystokinin-B receptor mRNAs.". Recept. Channels 6 (3): 165-77. PMID 10100325. 
  • Daulhac L, Kowalski-Chauvel A, Pradayrol L, et al. (1999). "Src-family tyrosine kinases in activation of ERK-1 and p85/p110-phosphatidylinositol 3-kinase by G/CCKB receptors.". J. Biol. Chem. 274 (29): 20657-63. PMID 10400698. 
  • Silvente-Poirot S, Escrieut C, Galès C, et al. (1999). "Evidence for a direct interaction between the penultimate aspartic acid of cholecystokinin and histidine 207, located in the second extracellular loop of the cholecystokinin B receptor.". J. Biol. Chem. 274 (33): 23191-7. PMID 10438490. 
  • Kulaksiz H, Arnold R, Göke B, et al. (2000). "Expression and cell-specific localization of the cholecystokinin B/gastrin receptor in the human stomach.". Cell Tissue Res. 299 (2): 289-98. PMID 10741470. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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v • d • e
Transmembrane receptor: G protein-coupled receptors
Class A: Rhodopsin like
Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)
Class B: Secretin like
Class C: Metabotropic
glutamate / pheromone
Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))
Frizzled / Smoothened
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened
v • d • e
Neuropeptide receptors
Hypothalamic hormone receptors
Pituitary hormone receptors
Other hormone receptors
Opioid receptors
Other neuropeptide receptors