Calcitonin gene-related peptide receptor

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It has been suggested that this article or section be merged with CALCRL. (Discuss)

calcitonin receptor-like receptor
Identifiers
Symbol	CALCRL
Entrez	10203
HUGO	16709
OMIM	114190
RefSeq	NM_005795
UniProt	Q16602
Other data
Locus	Chr. 2 q21.1-21.3

The calcitonin gene-related peptide receptors consist of a 7-transmembrane G-protein coupled, calcitonin receptor-like receptor (CL) linked to one of three single transmembrane domain receptor activity-modifying proteins (RAMPs) that are essential for functional activity.

The association of CL with different RAMP proteins produces different receptors:

• with RAMP1: produces a CGRP receptor
• with RAMP2: produces an Adrenomedullin receptor
• with RAMP3: produces a dual CGRP/AM receptor

These receptors are linked to the G protein G_s^[1], which activates adenylate cyclase and activation results in the generation of intracellular cyclic adenosine monophosphate (cAMP).

[edit] References

1. ^ senselab

[edit] External links

• MeSH calcitonin+receptor-like+receptor

v • d • e Neuropeptide receptors Hypothalamic hormone receptors CRH - FSH - LHRH - TRH - Somatostatin Pituitary hormone receptors Vasopressin (1A, 1B, 2) - Oxytocin - LHCG - Type I cytokine receptor (GH, Prolactin) - TSH Other hormone receptors Atrial natriuretic factor - Calcitonin - Cholecystokinin (A, B) - VIP Opioid receptors Delta - Kappa - Mu - Sigma (1, 2) - Nociceptin Other neuropeptide receptors Angiotensin - Bradykinin (B1, B2) / Tachykinin (TACR1) - Calcitonin gene-related peptide - Galanin - GPCR neuropeptide (B/W, FF, S, Y) - Neurotensin