Receptor activity-modifying protein

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Receptor activity-modifying protein 1 (RAMP1)
Identifiers
Symbol RAMP1
Entrez 10267
HUGO 9843
OMIM 605153
RefSeq NM_005855
UniProt O60894
Other data
Locus Chr. 2 q36-37.1
Receptor activity-modifying protein 2 (RAMP2)
Identifiers
Symbol RAMP2
Entrez 10266
HUGO 9844
OMIM 605154
RefSeq NM_005854
UniProt O60895
Other data
Locus Chr. 17 q12-21.1
Receptor activity-modifying protein 1 (RAMP3)
Identifiers
Symbol RAMP3
Entrez 10268
HUGO 9845
OMIM 605155
RefSeq NM_005856
UniProt O60896
Other data
Locus Chr. 7 q13-p12

Receptor activity-modifying proteins (RAMPs) are a class of proteins which interact with and modulate the activities of several Class B G Protein-Coupled Receptors including the receptors for secretin, calcitonin (CT), glucagon, and vasoactive intestinal peptide (VIP).[1] There are three distinct types of RAMPs, designated RAMP1, RAMP2, and RAMP3, each encoded by a separate gene.[2]

[edit] External links

[edit] References

  1. ^ Sexton PM, Morfis M, Tilakaratne N, Hay DL, Udawela M, Christopoulos G, Christopoulos A (2006). "Complexing receptor pharmacology: modulation of family B G protein-coupled receptor function by RAMPs". Ann N Y Acad Sci 1070: 90–104. doi:10.1196/annals.1317.076. PMID 16888151. 
  2. ^ Young A (2005). "Amylin: Physiology and Pharmacology; Chapter 3: Receptor pharmacology". Advances in Pharmacology 52: 47–65. doi:10.1016/S1054-3589(05)52003-9. PMID 16492540. 


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