Platelet-activating factor receptor

From Wikipedia, the free encyclopedia

Identifiers

External IDs

OMIM: 173393 MGI: 106066 HomoloGene: 20260

Gene ontology
Molecular Function:	• receptor activity • platelet activating factor receptor activity • phospholipid binding
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• cytokine production • chemotaxis • inflammatory response • immune response • signal transduction • G-protein coupled receptor protein signaling pathway • antimicrobial humoral response • phosphoinositide-mediated signaling

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000952 (mRNA)
NP_000943 (protein)

XM_357441 (mRNA)
XP_357441 (protein)

Location

Chr 1: 28.35 - 28.39 Mb

Chr 4: 131.84 - 131.85 Mb

Pubmed search

[1]

[2]

The platelet-activating factor receptor is a G-protein coupled receptor which binds platelet-activating factor.^[1]^[2]

PTAFR shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.[supplied by OMIM]^[3]

[edit] References

^ Seyfried CE, Schweickart VL, Godiska R, Gray PW (1992). "The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1". Genomics 13 (3): 832–4. doi:10.1016/0888-7543(92)90162-L. PMID 1322356.
^ Ishii S, Nagase T, Shimizu T (2002). "Platelet-activating factor receptor". Prostaglandins Other Lipid Mediat. 68-69: 599–609. doi:10.1016/S0090-6980(02)00058-8. PMID 12432946.
^ Entrez Gene: PTAFR platelet-activating factor receptor.

[edit] Further reading

Shukla SD (1992). "Platelet-activating factor receptor and signal transduction mechanisms.". FASEB J. 6 (6): 2296–301. PMID 1312046.
Sugimoto T, Tsuchimochi H, McGregor CG, et al. (1993). "Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart.". Biochem. Biophys. Res. Commun. 189 (2): 617–24. PMID 1281995.
Seyfried CE, Schweickart VL, Godiska R, Gray PW (1992). "The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1.". Genomics 13 (3): 832–4. PMID 1322356.
Kunz D, Gerard NP, Gerard C (1992). "The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog.". J. Biol. Chem. 267 (13): 9101–6. PMID 1374385.
Ye RD, Prossnitz ER, Zou AH, Cochrane CG (1991). "Characterization of a human cDNA that encodes a functional receptor for platelet activating factor.". Biochem. Biophys. Res. Commun. 180 (1): 105–11. PMID 1656963.
Nakamura M, Honda Z, Izumi T, et al. (1991). "Molecular cloning and expression of platelet-activating factor receptor from human leukocytes.". J. Biol. Chem. 266 (30): 20400–5. PMID 1657923.
Haslam RJ, Williams KA, Davidson MM (1986). "Receptor-effector coupling in platelets: roles of guanine nucleotides.". Adv. Exp. Med. Biol. 192: 265–80. PMID 3010668.
Valone FH (1984). "Isolation of a platelet membrane protein which binds the platelet-activating factor 1-0-hexadecyl-2-acetyl-SN-glycero-3-phosphorylcholine.". Immunology 52 (1): 169–74. PMID 6325330.
Cundell DR, Gerard NP, Gerard C, et al. (1995). "Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor.". Nature 377 (6548): 435–8. doi:10.1038/377435a0. PMID 7566121.
Izumi T, Kishimoto S, Takano T, et al. (1995). "Expression of human platelet-activating factor receptor gene in EoL-1 cells following butyrate-induced differentiation.". Biochem. J. 305 ( Pt 3): 829–35. PMID 7848283.
Bito H, Honda Z, Nakamura M, Shimizu T (1994). "Cloning, expression and tissue distribution of rat platelet-activating-factor-receptor cDNA.". Eur. J. Biochem. 221 (1): 211–8. PMID 8168510.
Chase PB, Halonen M, Regan JW (1993). "Cloning of a human platelet-activating factor receptor gene: evidence for an intron in the 5'-untranslated region.". Am. J. Respir. Cell Mol. Biol. 8 (3): 240–4. PMID 8383507.
Mutoh H, Bito H, Minami M, et al. (1993). "Two different promoters direct expression of two distinct forms of mRNAs of human platelet-activating factor receptor.". FEBS Lett. 322 (2): 129–34. PMID 8387031.
Nakamura M, Honda Z, Matsumoto T, et al. (1993). "Isolation and properties of platelet-activating factor receptor cDNAs.". Journal of lipid mediators 6 (1-3): 163–8. PMID 8395240.
Kishimoto S, Shimadzu W, Izumi T, et al. (1996). "Regulation by IL-5 of expression of functional platelet-activating factor receptors on human eosinophils.". J. Immunol. 157 (9): 4126–32. PMID 8892648.
Chase PB, Yang JM, Thompson FH, et al. (1997). "Regional mapping of the human platelet-activating factor receptor gene (PTAFR) to 1p35-->p34.3 by fluorescence in situ hybridization.". Cytogenet. Cell Genet. 72 (2-3): 205–7. PMID 8978777.
Le Gouill C, Parent JL, Rola-Pleszczynski M, Stanková J (1997). "Role of the Cys90, Cys95 and Cys173 residues in the structure and function of the human platelet-activating factor receptor.". FEBS Lett. 402 (2-3): 203–8. PMID 9037196.
Ahmed A, Dearn S, Shams M, et al. (1998). "Localization, quantification, and activation of platelet-activating factor receptor in human endometrium during the menstrual cycle: PAF stimulates NO, VEGF, and FAKpp125.". FASEB J. 12 (10): 831–43. PMID 9657523.
Cargill M, Altshuler D, Ireland J, et al. (1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes.". Nat. Genet. 22 (3): 231–8. doi:10.1038/10290. PMID 10391209.

[edit] External links

This membrane protein-related article is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e Transmembrane receptor: G protein-coupled receptors

Class A: Rhodopsin like	Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)

Class B: Secretin like	Brain-specific angiogenesis inhibitor (1, 2, 3) - Cadherin (1, 2, 3) - Calcitonin - CD97 - Corticotropin-releasing hormone (1, 2) - EMR (1, 2, 3) - Glucagon (GR, GIPR, GLP1R, GLP2R) - Growth hormone releasing hormone - PACAPR1- GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157) - Latrophilin (1, 2, 3, ELTD1) - Parathyroid hormone (1, 2) - Secretin - Vasoactive intestinal peptide (1, 2)

Class C: Metabotropic glutamate / pheromone	Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))

Frizzled / Smoothened	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened