Neuropeptide FF receptor 2

From Wikipedia, the free encyclopedia


Neuropeptide FF receptor 2
Identifiers
Symbol(s) NPFFR2; GPR74; NPFF2; NPGPR
External IDs OMIM: 607449 MGI: 1860130 HomoloGene: 56982
Orthologs
Human Mouse
Entrez 10886 104443
Ensembl ENSG00000056291 ENSMUSG00000035528
Uniprot Q9Y5X5 Q924N0
Refseq NM_004885 (mRNA)
NP_004876 (protein)		 XM_973847 (mRNA)
XP_978941 (protein)
Location Chr 4: 73.12 - 73.23 Mb Chr 5: 90.6 - 90.66 Mb
Pubmed search [1] [2]

Neuropeptide FF receptor 2, also known as NPFFR2, is a human gene.[1]


[edit] See also

[edit] References

  1. ^ Entrez Gene: NPFFR2 neuropeptide FF receptor 2.

[edit] Further reading

  • Cikos S, Gregor P, Koppel J (1999). "Sequence and tissue distribution of a novel G-protein-coupled receptor expressed prominently in human placenta.". Biochem. Biophys. Res. Commun. 256 (2): 352-6. doi:10.1006/bbrc.1999.0332. PMID 10079187. 
  • Parker RM, Copeland NG, Eyre HJ, et al. (2000). "Molecular cloning and characterisation of GPR74 a novel G-protein coupled receptor closest related to the Y-receptor family.". Brain Res. Mol. Brain Res. 77 (2): 199-208. PMID 10837915. 
  • Elshourbagy NA, Ames RS, Fitzgerald LR, et al. (2000). "Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor.". J. Biol. Chem. 275 (34): 25965-71. doi:10.1074/jbc.M004515200. PMID 10851242. 
  • Bonini JA, Jones KA, Adham N, et al. (2001). "Identification and characterization of two G protein-coupled receptors for neuropeptide FF.". J. Biol. Chem. 275 (50): 39324-31. doi:10.1074/jbc.M004385200. PMID 11024015. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Laemmle B, Schindler M, Beilmann M, et al. (2003). "Characterization of the NPGP receptor and identification of a novel short mRNA isoform in human hypothalamus.". Regul. Pept. 111 (1-3): 21-9. PMID 12609745. 
  • Engström M, Wurster S, Savola JM, Panula P (2004). "Functional properties of Pfr(Tic)amide and BIBP3226 at human neuropeptide FF2 receptors.". Peptides 24 (12): 1947-54. PMID 15127947. 
  • Mollereau C, Mazarguil H, Zajac JM, Roumy M (2005). "Neuropeptide FF (NPFF) analogs functionally antagonize opioid activities in NPFF2 receptor-transfected SH-SY5Y neuroblastoma cells.". Mol. Pharmacol. 67 (3): 965-75. doi:10.1124/mol.104.004614. PMID 15608144. 
  • Ankö ML, Panula P (2006). "Regulation of endogenous human NPFF2 receptor by neuropeptide FF in SK-N-MC neuroblastoma cell line.". J. Neurochem. 96 (2): 573-84. doi:10.1111/j.1471-4159.2005.03581.x. PMID 16336216. 
  • Ankö ML, Ostergård M, Lintunen M, Panula P (2007). "Alternative splicing of human and mouse NPFF2 receptor genes: Implications to receptor expression.". FEBS Lett. 580 (30): 6955-60. doi:10.1016/j.febslet.2006.11.063. PMID 17157836. 
  • Dahlman I, Dicker A, Jiao H, et al. (2007). "A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis.". Am. J. Hum. Genet. 80 (6): 1115-24. doi:10.1086/518445. PMID 17503329. 
 This membrane protein-related article is a stub. You can help Wikipedia by expanding it.
v • d • e
Transmembrane receptor: G protein-coupled receptors
Class A: Rhodopsin like
Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)
Class B: Secretin like
Class C: Metabotropic
glutamate / pheromone
Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))
Frizzled / Smoothened
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened