Bombesin

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Bombesin
Identifiers
CAS number	[31362-50-2]
PubChem	16133891
Properties
Molecular formula	C71H110N24O18S
Molar mass	1619.85
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

Bombesin is a 14 amino acid peptide originally isolated from the skin of a frog. It has two known homologs in mammals called neuromedin B and gastrin releasing peptide. It works on the gastrointestinal tract neuroendocrine hormone and it stimulates gastrin release from G cells. It activates three different G-protein coupled receptors known as BBR1 2 & 3. It also activates these receptors in the brain. Together with cholecystokinin it is the second major source of negative feedback signals that stop eating behaviour.

Bombesin is also a tumor marker for gastric cancer and neuroblastoma.

[edit] See also

• Neuromedin B
• Neuromedin U

v • d • e Peptides: neuropeptides Hypothalamic Somatostatin - CRH - GnRH - GHRH - Orexins - TRH - POMC (ACTH, MSH, Lipotropin) Gastrointestinal hormones Cholecystokinin - Gastric inhibitory polypeptide - Gastrin - Motilin - Secretin - Vasoactive intestinal peptide Other hormones Vasopressin - Calcitonin - Other Angiotensin - Bombesin/Neuromedin B - Calcitonin gene-related peptide - Carnosine - Delta sleep-inducing peptide - FMRFamide - Galanin - Gastrin releasing peptide - Kinins (Bradykinin, Tachykinins ) - Neuromedin (B, N, U) - Neuropeptide Y - Neurophysins - Neurotensin - Opioid peptide - Pancreatic polypeptide - Pituitary adenylate cyclase activating peptide