Cysteinyl leukotriene receptor 2

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Cysteinyl leukotriene receptor 2
Identifiers
Symbol(s) CYSLTR2; GPCR; CYSLT2; CYSLT2R; HG57; HPN321; KPG_011; PSEC0146; hGPCR21
External IDs OMIM: 605666 MGI: 1917336 HomoloGene: 10688
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 57105 70086
Ensembl ENSG00000152207 ENSMUSG00000033470
Uniprot Q9NS75 Q8R528
Refseq NM_020377 (mRNA)
NP_065110 (protein)		 NM_133720 (mRNA)
NP_598481 (protein)
Location Chr 13: 48.18 - 48.18 Mb Chr 14: 71.76 - 71.78 Mb
Pubmed search [1] [2]

Cysteinyl leukotriene receptor 2, also known as CYSLTR2, is a human gene.[1]

The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems.[1]

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: CYSLTR2 cysteinyl leukotriene receptor 2.

[edit] Further reading

  • Van Keer C, Kersters K, De Ley J (1976). "L-Sorbose metabolism in Agrobacterium tumefaciens.". Antonie Van Leeuwenhoek 42 (1-2): 13-24. PMID 1085123. 
  • Heise CE, O'Dowd BF, Figueroa DJ, et al. (2000). "Characterization of the human cysteinyl leukotriene 2 receptor.". J. Biol. Chem. 275 (39): 30531-6. doi:10.1074/jbc.M003490200. PMID 10851239. 
  • Takasaki J, Kamohara M, Matsumoto M, et al. (2000). "The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT(2) receptor.". Biochem. Biophys. Res. Commun. 274 (2): 316-22. doi:10.1006/bbrc.2000.3140. PMID 10913337. 
  • Nothacker HP, Wang Z, Zhu Y, et al. (2001). "Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist.". Mol. Pharmacol. 58 (6): 1601-8. PMID 11093801. 
  • Mita H, Hasegawa M, Saito H, Akiyama K (2002). "Levels of cysteinyl leukotriene receptor mRNA in human peripheral leucocytes: significantly higher expression of cysteinyl leukotriene receptor 2 mRNA in eosinophils.". Clin. Exp. Allergy 31 (11): 1714-23. PMID 11696047. 
  • Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence.". FEBS Lett. 520 (1-3): 97-101. PMID 12044878. 
  • Shirasaki H, Kanaizumi E, Watanabe K, et al. (2003). "Expression and localization of the cysteinyl leukotriene 1 receptor in human nasal mucosa.". Clin. Exp. Allergy 32 (7): 1007-12. PMID 12100046. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Sjöström M, Johansson AS, Schröder O, et al. (2004). "Dominant expression of the CysLT2 receptor accounts for calcium signaling by cysteinyl leukotrienes in human umbilical vein endothelial cells.". Arterioscler. Thromb. Vasc. Biol. 23 (8): e37-41. doi:10.1161/01.ATV.0000082689.46538.DF. PMID 12816881. 
  • Mellor EA, Frank N, Soler D, et al. (2003). "Expression of the type 2 receptor for cysteinyl leukotrienes (CysLT2R) by human mast cells: Functional distinction from CysLT1R.". Proc. Natl. Acad. Sci. U.S.A. 100 (20): 11589-93. doi:10.1073/pnas.2034927100. PMID 13679572. 
  • Thompson MD, Storm van's Gravesande K, Galczenski H, et al. (2004). "A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha.". Pharmacogenetics 13 (10): 641-9. doi:10.1097/01.fpc.0000054127.14659.42. PMID 14515063. 
  • Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522-8. doi:10.1038/nature02379. PMID 15057823. 
  • Fukai H, Ogasawara Y, Migita O, et al. (2005). "Association between a polymorphism in cysteinyl leukotriene receptor 2 on chromosome 13q14 and atopic asthma.". Pharmacogenetics 14 (10): 683-90. PMID 15454733. 
  • Pillai SG, Cousens DJ, Barnes AA, et al. (2005). "A coding polymorphism in the CYSLT2 receptor with reduced affinity to LTD4 is associated with asthma.". Pharmacogenetics 14 (9): 627-33. PMID 15475736. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Hui Y, Cheng Y, Smalera I, et al. (2005). "Directed vascular expression of human cysteinyl leukotriene 2 receptor modulates endothelial permeability and systemic blood pressure.". Circulation 110 (21): 3360-6. doi:10.1161/01.CIR.0000147775.50954.AA. PMID 15545522. 
  • Corrigan C, Mallett K, Ying S, et al. (2005). "Expression of the cysteinyl leukotriene receptors cysLT(1) and cysLT(2) in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis.". J. Allergy Clin. Immunol. 115 (2): 316-22. doi:10.1016/j.jaci.2004.10.051. PMID 15696087. 
  • Uzonyi B, Lötzer K, Jahn S, et al. (2006). "Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells.". Proc. Natl. Acad. Sci. U.S.A. 103 (16): 6326-31. doi:10.1073/pnas.0601223103. PMID 16606835. 
  • Woszczek G, Chen LY, Nagineni S, et al. (2007). "IFN-gamma induces cysteinyl leukotriene receptor 2 expression and enhances the responsiveness of human endothelial cells to cysteinyl leukotrienes.". J. Immunol. 178 (8): 5262-70. PMID 17404310. 
  • Klotsman M, York TP, Pillai SG, et al. (2007). "Pharmacogenetics of the 5-lipoxygenase biosynthetic pathway and variable clinical response to montelukast.". Pharmacogenet. Genomics 17 (3): 189-96. doi:10.1097/FPC.0b013e3280120043. PMID 17460547. 
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v • d • e
Transmembrane receptor: G protein-coupled receptors
Class A: Rhodopsin like
Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)
Class B: Secretin like
Class C: Metabotropic
glutamate / pheromone
Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))
Frizzled / Smoothened
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened

This article incorporates text from the United States National Library of Medicine, which is in the public domain.