CELSR1

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Cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
Identifiers
Symbol(s) CELSR1; ME2; CDHF9; DKFZp434P0729; FMI2; HFMI2
External IDs OMIM: 604523 MGI: 1100883 HomoloGene: 7665
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 9620 12614
Ensembl ENSG00000075275 ENSMUSG00000016028
Uniprot Q9NYQ6 Q571L9
Refseq NM_014246 (mRNA)
NP_055061 (protein)		 NM_009886 (mRNA)
NP_034016 (protein)
Location Chr 22: 45.14 - 45.31 Mb Chr 15: 85.73 - 85.86 Mb
Pubmed search [1] [2]

Cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila), also known as CELSR1, is a human gene.[1]

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis.[1]

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila).

[edit] Further reading

  • Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.". J. Mol. Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267. 
  • Hadjantonakis AK, Sheward WJ, Harmar AJ, et al. (1997). "Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter.". Genomics 45 (1): 97–104. doi:10.1006/geno.1997.4892. PMID 9339365. 
  • Wu Q, Maniatis T (1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes.". Cell 97 (6): 779–90. PMID 10380929. 
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  • Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMID 10716726. 
  • Ghosh A (2000). "Dentritic growth: don't go says flamingo.". Neuron 28 (1): 3–4. PMID 11086974. 
  • Gross J, Grimm O, Ortega G, et al. (2002). "Mutational analysis of the neuronal cadherin gene CELSR1 and exclusion as a candidate for catatonic schizophrenia in a large family.". Psychiatr. Genet. 11 (4): 197–200. PMID 11807409. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Georgieva L, Nikolov I, Poriazova N, et al. (2004). "Genetic variation in the seven-pass transmembrane cadherin CELSR1: lack of association with schizophrenia.". Psychiatr. Genet. 13 (2): 103–6. doi:10.1097/01.ypg.0000057486.14812.03. PMID 12782967. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Carroll JS, Liu XS, Brodsky AS, et al. (2005). "Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1.". Cell 122 (1): 33–43. doi:10.1016/j.cell.2005.05.008. PMID 16009131. 
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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