XCR1

From Wikipedia, the free encyclopedia


Chemokine (C motif) receptor 1
Identifiers
Symbol(s) XCR1; CCXCR1; GPR5
External IDs OMIM: 600552 MGI: 1346338 HomoloGene: 21095
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2829 23832
Ensembl ENSG00000173578 ENSMUSG00000060509
Uniprot P46094 Q544D8
Refseq NM_001024644 (mRNA)
NP_001019815 (protein)		 NM_011798 (mRNA)
NP_035928 (protein)
Location Chr 3: 46.04 - 46.04 Mb Chr 9: 123.7 - 123.71 Mb
Pubmed search [1] [2]

The "C" sub-family of chemokine receptors contains only one member: XCR1, the receptor for XCL1 and XCL2 (or lymphotactin-1 and -2).

XCR1 is also known as GPR5.

The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.[1]

[edit] References

  1. ^ Entrez Gene: XCR1 chemokine (C motif) receptor 1.

[edit] Further reading

  • Maghazachi AA (1999). "Intracellular signalling pathways induced by chemokines in natural killer cells.". Cell. Signal. 11 (6): 385–90. PMID 10400311. 
  • Gao JL, Kuhns DB, Tiffany HL, et al. (1993). "Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor.". J. Exp. Med. 177 (5): 1421–7. PMID 7683036. 
  • Heiber M, Docherty JM, Shah G, et al. (1995). "Isolation of three novel human genes encoding G protein-coupled receptors.". DNA Cell Biol. 14 (1): 25–35. PMID 7832990. 
  • Yoshida T, Imai T, Kakizaki M, et al. (1998). "Identification of single C motif-1/lymphotactin receptor XCR1.". J. Biol. Chem. 273 (26): 16551–4. PMID 9632725. 
  • Shan L, Qiao X, Oldham E, et al. (2000). "Identification of viral macrophage inflammatory protein (vMIP)-II as a ligand for GPR5/XCR1.". Biochem. Biophys. Res. Commun. 268 (3): 938–41. doi:10.1006/bbrc.2000.2235. PMID 10679309. 
  • Maho A, Bensimon A, Vassart G, Parmentier M (2000). "Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome.". Cytogenet. Cell Genet. 87 (3-4): 265–8. PMID 10702689. 
  • Kurt RA, Bauck M, Harma S, et al. (2001). "Role of C chemokine lymphotactin in mediating recruitment of antigen-specific CD62L(lo) cells in vitro and in vivo.". Cell. Immunol. 209 (2): 83–8. doi:10.1006/cimm.2001.1790. PMID 11446740. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Shinkai H, Morozumi T, Toki D, et al. (2005). "Genomic structure of eight porcine chemokine receptors and intergene sharing of an exon between CCR1 and XCR1.". Gene 349: 55–66. doi:10.1016/j.gene.2004.10.017. PMID 15777643. 
  • Lüttichau HR, Johnsen AH, Jurlander J, et al. (2007). "Kaposi sarcoma-associated herpes virus targets the lymphotactin receptor with both a broad spectrum antagonist vCCL2 and a highly selective and potent agonist vCCL3.". J. Biol. Chem. 282 (24): 17794–805. doi:10.1074/jbc.M702001200. PMID 17403668. 

[edit] External links

 This membrane protein-related article is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e
G protein-coupled receptors, cytokine receptors: chemokine receptors
CC chemokine receptors
CXC chemokine receptors
Other
CCBP2 - CMKLR1 - CX3CR1 - XCR1