CCBP2

From Wikipedia, the free encyclopedia


Chemokine binding protein 2
Identifiers
Symbol(s) CCBP2; CCR10; CCR9; CMKBR9; D6; MGC126678; MGC138250; hD6
External IDs OMIM: 602648 MGI: 1891697 HomoloGene: 992
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 1238 59289
Ensembl ENSG00000144648 ENSMUSG00000044534
Uniprot O00590 Q2V6T2
Refseq NM_001296 (mRNA)
NP_001287 (protein)		 NM_021609 (mRNA)
NP_067622 (protein)
Location Chr 3: 42.84 - 42.88 Mb Chr 9: 121.75 - 121.76 Mb
Pubmed search [1] [2]

Chemokine binding protein 2, also known as CCBP2, is a human gene.[1]

This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.[1]

[edit] References

  1. ^ a b Entrez Gene: CCBP2 chemokine binding protein 2.

[edit] Further reading

  • Nibbs RJ, Wylie SM, Pragnell IB, Graham GJ (1997). "Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5.". J. Biol. Chem. 272 (19): 12495–504. PMID 9139699. 
  • Bonini JA, Martin SK, Dralyuk F, et al. (1997). "Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3.". DNA Cell Biol. 16 (10): 1249–56. PMID 9364936. 
  • Nibbs RJ, Wylie SM, Yang J, et al. (1998). "Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6.". J. Biol. Chem. 272 (51): 32078–83. PMID 9405404. 
  • Nibbs RJ, Yang J, Landau NR, et al. (1999). "LD78beta, a non-allelic variant of human MIP-1alpha (LD78alpha), has enhanced receptor interactions and potent HIV suppressive activity.". J. Biol. Chem. 274 (25): 17478–83. PMID 10364178. 
  • Maho A, Bensimon A, Vassart G, Parmentier M (2000). "Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome.". Cytogenet. Cell Genet. 87 (3-4): 265–8. PMID 10702689. 
  • Gosling J, Dairaghi DJ, Wang Y, et al. (2000). "Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK.". J. Immunol. 164 (6): 2851–6. PMID 10706668. 
  • Jarmin DI, Rits M, Bota D, et al. (2000). "Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine.". J. Immunol. 164 (7): 3460–4. PMID 10725696. 
  • Homey B, Wang W, Soto H, et al. (2000). "Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC).". J. Immunol. 164 (7): 3465–70. PMID 10725697. 
  • Wang W, Soto H, Oldham ER, et al. (2000). "Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2).". J. Biol. Chem. 275 (29): 22313–23. doi:10.1074/jbc.M001461200. PMID 10781587. 
  • Nibbs RJ, Kriehuber E, Ponath PD, et al. (2001). "The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors.". Am. J. Pathol. 158 (3): 867–77. PMID 11238036. 
  • Homey B, Alenius H, Müller A, et al. (2002). "CCL27-CCR10 interactions regulate T cell-mediated skin inflammation.". Nat. Med. 8 (2): 157–65. doi:10.1038/nm0202-157. PMID 11821900. 
  • Soler D, Humphreys TL, Spinola SM, Campbell JJ (2003). "CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking.". Blood 101 (5): 1677–82. doi:10.1182/blood-2002-07-2348. PMID 12406880. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Fra AM, Locati M, Otero K, et al. (2003). "Cutting edge: scavenging of inflammatory CC chemokines by the promiscuous putatively silent chemokine receptor D6.". J. Immunol. 170 (5): 2279–82. PMID 12594248. 
  • Kunkel EJ, Kim CH, Lazarus NH, et al. (2003). "CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells.". J. Clin. Invest. 111 (7): 1001–10. PMID 12671049. 
  • Galliera E, Jala VR, Trent JO, et al. (2004). "beta-Arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6.". J. Biol. Chem. 279 (24): 25590–7. doi:10.1074/jbc.M400363200. PMID 15084596. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Neil SJ, Aasa-Chapman MM, Clapham PR, et al. (2005). "The promiscuous CC chemokine receptor D6 is a functional coreceptor for primary isolates of human immunodeficiency virus type 1 (HIV-1) and HIV-2 on astrocytes.". J. Virol. 79 (15): 9618–24. doi:10.1128/JVI.79.15.9618-9624.2005. PMID 16014924. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

 This membrane protein-related article is a stub. You can help Wikipedia by expanding it.
v • d • e
G protein-coupled receptors, cytokine receptors: chemokine receptors
CC chemokine receptors
CXC chemokine receptors
Other
CCBP2 - CMKLR1 - CX3CR1 - XCR1