Formyl peptide receptor-like 2

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Formyl peptide receptor-like 2
Identifiers
Symbol(s) FPRL2; FPRH1; FPRH2; FML2_HUMAN; FMLPY; RMLP-R-I
External IDs OMIM: 136539 MGI: 1194495 HomoloGene: 40605
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 2359 14294
Ensembl ENSG00000187474 n/a
Uniprot P25089 n/a
Refseq NM_002030 (mRNA)
NP_002021 (protein)		 NM_008042 (mRNA)
NP_032068 (protein)
Location Chr 19: 56.99 - 57.02 Mb n/a
Pubmed search [1] [2]

Formyl peptide receptor-like 2, also known as FPRL2, is a human gene.[1]


[edit] See also

[edit] References

  1. ^ Entrez Gene: FPRL2 formyl peptide receptor-like 2.

[edit] Further reading

  • Bao L, Gerard NP, Eddy RL, et al. (1992). "Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19.". Genomics 13 (2): 437-40. PMID 1612600. 
  • Durstin M, Gao JL, Tiffany HL, et al. (1994). "Differential expression of members of the N-formylpeptide receptor gene cluster in human phagocytes.". Biochem. Biophys. Res. Commun. 201 (1): 174-9. doi:10.1006/bbrc.1994.1685. PMID 8198572. 
  • Christophe T, Karlsson A, Dugave C, et al. (2001). "The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2.". J. Biol. Chem. 276 (24): 21585-93. doi:10.1074/jbc.M007769200. PMID 11285256. 
  • Yang D, Chen Q, Gertz B, et al. (2002). "Human dendritic cells express functional formyl peptide receptor-like-2 (FPRL2) throughout maturation.". J. Leukoc. Biol. 72 (3): 598-607. PMID 12223529. 
  • Christophe T, Karlsson A, Rabiet MJ, et al. (2002). "Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1/LXA4R, is not affected by lipoxin A4.". Scand. J. Immunol. 56 (5): 470-6. PMID 12410796. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Ernst S, Lange C, Wilbers A, et al. (2004). "An annexin 1 N-terminal peptide activates leukocytes by triggering different members of the formyl peptide receptor family.". J. Immunol. 172 (12): 7669-76. PMID 15187149. 
  • Harada M, Habata Y, Hosoya M, et al. (2004). "N-Formylated humanin activates both formyl peptide receptor-like 1 and 2.". Biochem. Biophys. Res. Commun. 324 (1): 255-61. doi:10.1016/j.bbrc.2004.09.046. PMID 15465011. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Kang HK, Lee HY, Kim MK, et al. (2005). "The synthetic peptide Trp-Lys-Tyr-Met-Val-D-Met inhibits human monocyte-derived dendritic cell maturation via formyl peptide receptor and formyl peptide receptor-like 2.". J. Immunol. 175 (2): 685-92. PMID 16002663. 
  • Lee HY, Lee SY, Shin EH, et al. (2007). "F2L, a peptide derived from heme-binding protein, inhibits formyl peptide receptor-mediated signaling.". Biochem. Biophys. Res. Commun. 359 (4): 985-90. doi:10.1016/j.bbrc.2007.06.001. PMID 17577578. 
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v • d • e
Transmembrane receptor: G protein-coupled receptors
Class A: Rhodopsin like
Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)
Class B: Secretin like
Class C: Metabotropic
glutamate / pheromone
Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))
Frizzled / Smoothened
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened