EGF-like domain

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EGF-like domain
Identifiers
Symbol	EGF
Pfam	PF00008
InterPro	IPR006209
PROSITE	PDOC00021
SCOP	1apo
OPM protein	1dan
Available PDB structures: 1tpg :86-119 1haf :182-221 1hae :182-221 1hrf :182-221 1hre :182-221 1tozA:456-487 1wv7L:110-141 1j9cL:110-141 1ff7A:110-141 1wqvL:110-141 1bf9 :110-141 1f7mA:110-141 1wssL:110-141 1nl8M:110-141 1w0yL:110-141 1dvaM:110-141 1z6jL:110-141 1fakL:110-141 1f7eA:110-141 1wunL:110-141 1wtgL:110-141 1qfkL:110-141 1o5dL:110-141 1ffmA:110-141 1danL:110-141 1xkbB:90-121 1xkaL:90-121 1apo :90-121 1whf :90-121 1whe :90-121 1ccf :90-121 1edmC:97-128 1ixa :97-128 1pfxL:52-83 1x7aL:52-83 1pz8C:1836-1869 1q56A:1836-1869 1pz7B:1836-1869 1pz9B:1836-1869 1pgfB:37-69 1pthA:37-69 1prhB:37-69 1q4gB:37-69 1pggA:37-69 1ebvA:37-69 1fe2A:37-69 1ht5B:37-69 1cqeB:37-69 1diyA:37-69 2aylA:37-69 1eqgA:37-69 1pgeA:37-69 1igzA:37-69 1ht8A:37-69 1eqhB:37-69 1igxA:37-69 1u67A:37-69 1djjA:37-69 1pxxB:21-54 5coxC:21-54 1ddxA:21-54 1cvuA:21-54 1dd0A:21-54 1cx2B:21-54 3pghC:21-54 4coxB:21-54 1dcxB:21-54 6coxB:21-54 1v0xA:22-54 1g1qA:163-194 1g1sB:163-194 1g1rB:163-194 1fsb :163-194 1esl :143-174 1g1tA:143-174 1nziA:135-171 1k36A:68-103 1k37A:68-103 1ivoD:976-1012 1jl9B:976-1012 1nqlB:976-1012 1a3p :982-1018 1epj :982-1018 1epg :982-1018 3egf :982-1018 1egf :982-1018 1eph :982-1018 1epi :982-1018 1ioxA:69-104 1ip0A:69-104 4tgf :47-82 2tgf :47-82 1moxD:47-82 1yug :47-82 1yuf :47-82 3tgf :47-82 1xdtR:108-143 1ijqA:667-711 1n7dA:667-711 1xfeA:318-352 1i0uA:318-352 1hj7A:318-352 1hz8A:318-352 1rfnB:134-170 1ezqB:129-164 1c5mF:129-164 1ksnB:129-164 1ioeL:129-164 2bokL:129-164 1hcgB:129-164 1iqjL:129-164 1iqlL:129-164 1nfuB:129-164 1faxL:129-164 1lpzA:129-164 1f0rB:129-164 1g2lB:129-164 1g2mB:129-164 1nfwB:129-164 1p0sL:129-164 1nfxB:129-164 1v3xB:129-164 1iqkL:129-164 1lqdA:129-164 1lpkA:129-164 1nfyB:129-164 1iqgL:129-164 1wu1B:129-164 1fjsL:129-164 1lpgA:129-164 1iqhL:129-164 1iqiL:129-164 1f0sB:129-164 1mq5L:129-164 1iqmL:129-164 1iqeL:129-164 1iqfL:129-164 1iqnL:129-164 1mq6L:129-164 1kyeB:129-164 1kigL:129-164 1yo8A:652-691 1gl4A:388-423 1h4uA:395-423 1cejA:1574-1617 1ob1F:474-517

EGF-like domain is an evolutionary conserved protein domain, of about thirty to forty amino-acid residues long, which was found in a large number of mostly animal proteins. All these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (except in prostaglandin H/G synthase). The EGF domain includes six cysteine residues which have been shown (in EGF) to be involved in three disulfide bonds. The main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet.

Pfam PF00053 family is very similar, but has 8 instead of 6 conserved cysteines.

This family includes some cytokine receptors.

[edit] Human proteins containing this domain

AGC1; AGRIN; AREG; ATRN; ATRNL1; BCAN; BMP1; BTC; C1S; CASPR4; CD248; CD93; CELSR1; CELSR2; CELSR3; CNTNAP1; CNTNAP2; CNTNAP3; CNTNAP4; CNTNAP5; COMP; COX-2; CRB1; CRB2; CSPG3; CUBN; DLK1; DLL1; DLL3; DLL4; DNER; EDIL3; EGF; EGFL11; EGFL8; EGFL9; EGFLAM; EPGN; EREG; F10; F12; F7; F9; FAT; FAT2; FAT4; FBN1; FBN2; FBN3; GAS6; HABP2; HBEGF; HEG1; HGFAC; HMCN1; HSPG2; ITGB5; JAG1; JAG2; LDLR; LRP1; LRP10; LRP1B; LRP2; LRP4; LRP5; LRP6; LRP8; LTBP1; LTBP2; LTBP3; LTBP4; MATN1; MATN2; MATN3; MATN4; MEGF12; MEGF6; MEP1A; MEP1B; MFGE8; MMRN; MMRN1; MUC4; NAGPA; NID1; NID2; NOTCH1; NOTCH2; NOTCH2NL; NOTCH3; NOTCH4; NRG1; NRG2; NRG3; NRG4; NRXN1; NRXN2; NRXN3; NTNG2; ODZ1; ODZ2; ODZ3; OIT3; PLAT; PP187; PROC; PROS1; PROZ; PTGS1; PTGS2; RAMP; RESDA1; SCUBE1; SCUBE2; SCUBE3; SEL-OB; SELE; SELL; SELP; SLIT1; SLIT2; SLIT3; SNED1; STAB1; STAB2; SVEP1; TECTA; TGFA; THBD; THBS1; THBS2; THBS4; TIE1; TLL1; TLL2; TMEFF1; TMEFF2; TNC; TNXB; UMOD; VASN; VCAN; VLDLR; VWA2; WIF1; ZAN; dJ34F7.1;

[edit] References

[1]. Solution structure of a pair of calcium-binding epidermal growth factor-like domains: implications for the Marfan syndrome and other genetic disorders. Downing AK, Knott V, Werner JM, Cardy CM, Campbell ID, Handford PA; Cell 1996;85:597-605. PubMed
[2]. Structure and distribution of modules in extracellular proteins. Bork P, Downing AK, Kieffer B, Campbell ID; Q Rev Biophys 1996;29:119-167. PubMed