VCAN

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It has been suggested that this article or section be merged into Versican. (Discuss)

Versican

Identifiers

Symbol(s)

VCAN; CSPG2; DKFZp686K06110; ERVR; PG-M; WGN; WGN1

External IDs

OMIM: 118661 MGI: 102889 HomoloGene: 3228

Gene ontology
Molecular Function:	• calcium ion binding • sugar binding • hyaluronic acid binding
Cellular Component:	• proteinaceous extracellular matrix
Biological Process:	• cell adhesion • multicellular organismal development • cell recognition

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004385 (mRNA)
NP_004376 (protein)

XM_488510 (mRNA)
XP_488510 (protein)

Location

Chr 5: 82.8 - 82.91 Mb

Chr 13: 90.13 - 90.22 Mb

Pubmed search

[1]

[2]

Versican, also known as VCAN, is a human gene.^[1]

[edit] References

^ Entrez Gene: VCAN versican.

[edit] Further reading

Wight TN, Merrilees MJ (2004). "Proteoglycans in atherosclerosis and restenosis: key roles for versican.". Circ. Res. 94 (9): 1158–67. doi:10.1161/01.RES.0000126921.29919.51. PMID 15142969.
Kenagy RD, Plaas AH, Wight TN (2006). "Versican degradation and vascular disease.". Trends Cardiovasc. Med. 16 (6): 209–15. doi:10.1016/j.tcm.2006.03.011. PMID 16839865.
Perides G, Rahemtulla F, Lane WS, et al. (1992). "Isolation of a large aggregating proteoglycan from human brain.". J. Biol. Chem. 267 (33): 23883–7. PMID 1429726.
Iozzo RV, Naso MF, Cannizzaro LA, et al. (1993). "Mapping of the versican proteoglycan gene (CSPG2) to the long arm of human chromosome 5 (5q12-5q14).". Genomics 14 (4): 845–51. PMID 1478664.
Perides G, Lane WS, Andrews D, et al. (1989). "Isolation and partial characterization of a glial hyaluronate-binding protein.". J. Biol. Chem. 264 (10): 5981–7. PMID 2466833.
Bignami A, Lane WS, Andrews D, Dahl D (1989). "Structural similarity of hyaluronate binding proteins in brain and cartilage.". Brain Res. Bull. 22 (1): 67–70. PMID 2469524.
Zimmermann DR, Ruoslahti E (1990). "Multiple domains of the large fibroblast proteoglycan, versican.". EMBO J. 8 (10): 2975–81. PMID 2583089.
Krusius T, Gehlsen KR, Ruoslahti E (1987). "A fibroblast chondroitin sulfate proteoglycan core protein contains lectin-like and growth factor-like sequences.". J. Biol. Chem. 262 (27): 13120–5. PMID 2820964.
Naso MF, Zimmermann DR, Iozzo RV (1995). "Characterization of the complete genomic structure of the human versican gene and functional analysis of its promoter.". J. Biol. Chem. 269 (52): 32999–3008. PMID 7528742.
Brown DM, Graemiger RA, Hergersberg M, et al. (1995). "Genetic linkage of Wagner disease and erosive vitreoretinopathy to chromosome 5q13-14.". Arch. Ophthalmol. 113 (5): 671–5. PMID 7748141.
Dours-Zimmermann MT, Zimmermann DR (1995). "A novel glycosaminoglycan attachment domain identified in two alternative splice variants of human versican.". J. Biol. Chem. 269 (52): 32992–8. PMID 7806529.
Zako M, Shinomura T, Ujita M, et al. (1995). "Expression of PG-M(V3), an alternatively spliced form of PG-M without a chondroitin sulfate attachment in region in mouse and human tissues.". J. Biol. Chem. 270 (8): 3914–8. PMID 7876137.
Yao LY, Moody C, Schönherr E, et al. (1994). "Identification of the proteoglycan versican in aorta and smooth muscle cells by DNA sequence analysis, in situ hybridization and immunohistochemistry.". Matrix Biol. 14 (3): 213–25. PMID 7921538.
Bode-Lesniewska B, Dours-Zimmermann MT, Odermatt BF, et al. (1996). "Distribution of the large aggregating proteoglycan versican in adult human tissues.". J. Histochem. Cytochem. 44 (4): 303–12. PMID 8601689.
Paulus W, Baur I, Dours-Zimmermann MT, Zimmermann DR (1996). "Differential expression of versican isoforms in brain tumors.". J. Neuropathol. Exp. Neurol. 55 (5): 528–33. PMID 8627343.
Sartipy P, Johansen B, Camejo G, et al. (1996). "Binding of human phospholipase A2 type II to proteoglycans. Differential effect of glycosaminoglycans on enzyme activity.". J. Biol. Chem. 271 (42): 26307–14. PMID 8824283.
Aspberg A, Miura R, Bourdoulous S, et al. (1997). "The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety.". Proc. Natl. Acad. Sci. U.S.A. 94 (19): 10116–21. PMID 9294172.
Sartipy P, Bondjers G, Hurt-Camejo E (1999). "Phospholipase A2 type II binds to extracellular matrix biglycan: modulation of its activity on LDL by colocalization in glycosaminoglycan matrixes.". Arterioscler. Thromb. Vasc. Biol. 18 (12): 1934–41. PMID 9848887.
Perveen R, Hart-Holden N, Dixon MJ, et al. (1999). "Refined genetic and physical localization of the Wagner disease (WGN1) locus and the genes CRTL1 and CSPG2 to a 2- to 2.5-cM region of chromosome 5q14.3.". Genomics 57 (2): 219–26. doi:10.1006/geno.1999.5766. PMID 10198161.
Lemire JM, Braun KR, Maurel P, et al. (1999). "Versican/PG-M isoforms in vascular smooth muscle cells.". Arterioscler. Thromb. Vasc. Biol. 19 (7): 1630–9. PMID 10397680.