THBS1

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Thrombospondin 1
PDB rendering based on 1lsl.
Available structures: 1lsl, 1ux6, 1z78, 1za4, 2erf, 2es3
Identifiers
Symbol(s)	THBS1; THBS; TSP; TSP1
External IDs	OMIM: 188060 MGI: 98737 HomoloGene: 31142
Gene ontology Molecular Function: • endopeptidase inhibitor activity • signal transducer activity • structural molecule activity • calcium ion binding • protein binding • heparin binding Cellular Component: • extracellular region • extracellular space Biological Process: • cell motility • inflammatory response • cell adhesion • multicellular organismal development • nervous system development • blood coagulation • negative regulation of angiogenesis
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	7057	21825
Ensembl	ENSG00000137801	n/a
Uniprot	P07996	n/a
Refseq	NM_003246 (mRNA) NP_003237 (protein)	NM_011580 (mRNA) NP_035710 (protein)
Location	Chr 15: 37.66 - 37.68 Mb	n/a
Pubmed search	[1]	[2]

Thrombospondin 1, also known as THBS1, is a human gene.

The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis.^[1]

[edit] See also

Thrombospondin

[edit] References

[edit] Further reading