WIF1

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WNT inhibitory factor 1
PDB rendering based on 2d3j.
Available structures: 2d3j
Identifiers
Symbol(s) WIF1; WIF-1
External IDs OMIM: 605186 MGI: 1344332 HomoloGene: 31430
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 11197 24117
Ensembl ENSG00000156076 ENSMUSG00000020218
Uniprot Q9Y5W5 Q3TYU1
Refseq NM_007191 (mRNA)
NP_009122 (protein)		 XM_983228 (mRNA)
XP_988322 (protein)
Location Chr 12: 63.73 - 63.8 Mb Chr 10: 120.44 - 120.5 Mb
Pubmed search [1] [2]

WNT inhibitory factor 1, also known as WIF1, is a human gene.[1]

WNT proteins are extracellular signaling molecules involved in the control of embryonic development. This gene encodes a secreted protein, which binds WNT proteins and inhibits their activities. This protein contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. It may be involved in mesoderm segmentation. This protein is found to be present in fish, amphibia and mammals.[1]

[edit] References

  1. ^ a b Entrez Gene: WIF1 WNT inhibitory factor 1.

[edit] Further reading

  • Malinauskas T (2008). "Docking of fatty acids into the WIF domain of the human Wnt inhibitory factor-1". Lipids 43 (3): 227-30. doi:10.1007/s11745-007-3144-3. PMID 18256869. 
  • Shepelev MV, Korobko EV, Korobko IV (2006). "[WIF1: perspectives of application in oncology]". Mol. Gen. Mikrobiol. Virusol. (4): 3-7. PMID 17094650. 
  • Hsieh JC, Kodjabachian L, Rebbert ML, et al. (1999). "A new secreted protein that binds to Wnt proteins and inhibits their activities.". Nature 398 (6726): 431-6. doi:10.1038/18899. PMID 10201374. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Reguart N, He B, Xu Z, et al. (2004). "Cloning and characterization of the promoter of human Wnt inhibitory factor-1.". Biochem. Biophys. Res. Commun. 323 (1): 229-34. doi:10.1016/j.bbrc.2004.08.075. PMID 15351726. 
  • Esufali S, Bapat B (2004). "Cross-talk between Rac1 GTPase and dysregulated Wnt signaling pathway leads to cellular redistribution of beta-catenin and TCF/LEF-mediated transcriptional activation.". Oncogene 23 (50): 8260-71. doi:10.1038/sj.onc.1208007. PMID 15377999. 
  • Ohigashi T, Mizuno R, Nakashima J, et al. (2005). "Inhibition of Wnt signaling downregulates Akt activity and induces chemosensitivity in PTEN-mutated prostate cancer cells.". Prostate 62 (1): 61-8. doi:10.1002/pros.20117. PMID 15389810. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Simon M, Grandage VL, Linch DC, Khwaja A (2005). "Constitutive activation of the Wnt/beta-catenin signalling pathway in acute myeloid leukaemia.". Oncogene 24 (14): 2410-20. doi:10.1038/sj.onc.1208431. PMID 15735743. 
  • Taniguchi H, Yamamoto H, Hirata T, et al. (2005). "Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers.". Oncogene 24 (53): 7946-52. doi:10.1038/sj.onc.1208910. PMID 16007117. 
  • Lin YC, You L, Xu Z, et al. (2006). "Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines.". Biochem. Biophys. Res. Commun. 341 (2): 635-40. doi:10.1016/j.bbrc.2005.12.220. PMID 16427602. 
  • Urakami S, Shiina H, Enokida H, et al. (2006). "Epigenetic inactivation of Wnt inhibitory factor-1 plays an important role in bladder cancer through aberrant canonical Wnt/beta-catenin signaling pathway.". Clin. Cancer Res. 12 (2): 383-91. doi:10.1158/1078-0432.CCR-05-1344. PMID 16428476. 
  • Liepinsh E, Bányai L, Patthy L, Otting G (2006). "NMR structure of the WIF domain of the human Wnt-inhibitory factor-1.". J. Mol. Biol. 357 (3): 942-50. doi:10.1016/j.jmb.2006.01.047. PMID 16476441. 
  • Batra S, Shi Y, Kuchenbecker KM, et al. (2006). "Wnt inhibitory factor-1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesothelioma.". Biochem. Biophys. Res. Commun. 342 (4): 1228-32. doi:10.1016/j.bbrc.2006.02.084. PMID 16516163. 
  • Chim CS, Chan WW, Pang A, Kwong YL (2006). "Preferential methylation of Wnt inhibitory factor-1 in acute promyelocytic leukemia: an independent poor prognostic factor.". Leukemia 20 (5): 907-9. doi:10.1038/sj.leu.2404176. PMID 16525492. 
  • Urakami S, Shiina H, Enokida H, et al. (2006). "Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection.". Clin. Cancer Res. 12 (7 Pt 1): 2109-16. doi:10.1158/1078-0432.CCR-05-2468. PMID 16609023. 
  • Milutinovic S, D'Alessio AC, Detich N, Szyf M (2007). "Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes.". Carcinogenesis 28 (3): 560-71. doi:10.1093/carcin/bgl167. PMID 17012225. 
  • Queimado L, Lopes CS, Reis AM (2007). "WIF1, an inhibitor of the Wnt pathway, is rearranged in salivary gland tumors.". Genes Chromosomes Cancer 46 (3): 215-25. doi:10.1002/gcc.20402. PMID 17171686. 
  • Chan SL, Cui Y, van Hasselt A, et al. (2007). "The tumor suppressor Wnt inhibitory factor 1 is frequently methylated in nasopharyngeal and esophageal carcinomas.". Lab. Invest. 87 (7): 644-50. doi:10.1038/labinvest.3700547. PMID 17384664. 
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