SLIT3

From Wikipedia, the free encyclopedia

Slit homolog 3 (Drosophila)

Identifiers

SLIT3; SLIT1; FLJ10764; MEGF5; SLIL2; Slit-3; slit2

External IDs

OMIM: 603745 MGI: 1315202 HomoloGene: 2303

Gene ontology
Molecular Function:	• structural molecule activity • calcium ion binding • protein binding
Cellular Component:	• extracellular space
Biological Process:	• multicellular organismal development • axon guidance • central nervous system development • organ morphogenesis • cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003062 (mRNA)
NP_003053 (protein)

NM_011412 (mRNA)
NP_035542 (protein)

Location

Chr 5: 168.03 - 168.66 Mb

Chr 11: 34.96 - 35.55 Mb

Pubmed search

[1]

[2]

Slit homolog 3 (Drosophila), also known as SLIT3, is a human gene.^[1]

[edit] References

^ Entrez Gene: SLIT3 slit homolog 3 (Drosophila).

[edit] Further reading

Nakayama M, Nakajima D, Nagase T, et al. (1998). "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.". Genomics 51 (1): 27-34. doi:10.1006/geno.1998.5341. PMID 9693030.
Itoh A, Miyabayashi T, Ohno M, Sakano S (1999). "Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system.". Brain Res. Mol. Brain Res. 62 (2): 175-86. PMID 9813312.
Holmes GP, Negus K, Burridge L, et al. (1999). "Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis.". Mech. Dev. 79 (1-2): 57-72. PMID 10349621.
Little MH, Wilkinson L, Brown DL, et al. (2001). "Dual trafficking of Slit3 to mitochondria and cell surface demonstrates novel localization for Slit protein.". Am. J. Physiol., Cell Physiol. 281 (2): C486-95. PMID 11443047.
Marillat V, Cases O, Nguyen-Ba-Charvet KT, et al. (2002). "Spatiotemporal expression patterns of slit and robo genes in the rat brain.". J. Comp. Neurol. 442 (2): 130-55. PMID 11754167.
Little M, Rumballe B, Georgas K, et al. (2003). "Conserved modularity and potential for alternate splicing in mouse and human Slit genes.". Int. J. Dev. Biol. 46 (4): 385-91. PMID 12141424.
Jiang LQ, Wen SJ, Wang HY, Chen LY (2003). "Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system.". Hypertens. Res. 25 (4): 647-52. PMID 12358155.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Shi Y, Zhao X, Yu L, et al. (2004). "Genetic structure adds power to detect schizophrenia susceptibility at SLIT3 in the Chinese Han population.". Genome Res. 14 (7): 1345-9. doi:10.1101/gr.1758204. PMID 15231749.
Hammond R, Vivancos V, Naeem A, et al. (2005). "Slit-mediated repulsion is a key regulator of motor axon pathfinding in the hindbrain.". Development 132 (20): 4483-95. doi:10.1242/dev.02038. PMID 16162649.
Lin L, Isacson O (2006). "Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits.". Stem Cells 24 (11): 2504-13. doi:10.1634/stemcells.2006-0119. PMID 16840550.