HGFAC

From Wikipedia, the free encyclopedia


HGF activator
PDB rendering based on 1ybw.
Available structures: 1ybw, 1yc0
Identifiers
Symbol(s) HGFAC; HGFA; MGC138395; MGC138397
External IDs OMIM: 604552 MGI: 1859281 HomoloGene: 1170
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 3083 54426
Ensembl ENSG00000109758 ENSMUSG00000029102
Uniprot Q04756 Q3TDU8
Refseq NM_001528 (mRNA)
NP_001519 (protein)		 NM_019447 (mRNA)
NP_062320 (protein)
Location Chr 4: 3.41 - 3.42 Mb Chr 5: 35.36 - 35.37 Mb
Pubmed search [1] [2]

HGF activator, also known as HGFAC, is a human gene.[1]

The protein encoded by this gene belongs to peptidase family S1. It is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form.[1]

[edit] References

  1. ^ a b Entrez Gene: HGFAC HGF activator.

[edit] Further reading

  • Nakamura T (1992). "Structure and function of hepatocyte growth factor.". Prog. Growth Factor Res. 3 (1): 67–85. PMID 1838014. 
  • Shimomura T, Ochiai M, Kondo J, Morimoto Y (1992). "A novel protease obtained from FBS-containing culture supernatant, that processes single chain form hepatocyte growth factor to two chain form in serum-free culture.". Cytotechnology 8 (3): 219–29. PMID 1368819. 
  • Miyazawa K, Shimomura T, Kitamura A, et al. (1993). "Molecular cloning and sequence analysis of the cDNA for a human serine protease reponsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII.". J. Biol. Chem. 268 (14): 10024–8. PMID 7683665. 
  • Shimomura T, Kondo J, Ochiai M, et al. (1993). "Activation of the zymogen of hepatocyte growth factor activator by thrombin.". J. Biol. Chem. 268 (30): 22927–32. PMID 8226803. 
  • Miyazawa K, Shimomura T, Kitamura N (1996). "Activation of hepatocyte growth factor in the injured tissues is mediated by hepatocyte growth factor activator.". J. Biol. Chem. 271 (7): 3615–8. PMID 8631970. 
  • Shimomura T, Denda K, Kitamura A, et al. (1997). "Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor.". J. Biol. Chem. 272 (10): 6370–6. PMID 9045658. 
  • Kawaguchi T, Qin L, Shimomura T, et al. (1997). "Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor.". J. Biol. Chem. 272 (44): 27558–64. PMID 9346890. 
  • Miyazawa K, Wang Y, Minoshima S, et al. (1999). "Structural organization and chromosomal localization of the human hepatocyte growth factor activator gene--phylogenetic and functional relationship with blood coagulation factor XII, urokinase, and tissue-type plasminogen activator.". Eur. J. Biochem. 258 (2): 355–61. PMID 9874200. 
  • Kataoka H, Shimomura T, Kawaguchi T, et al. (2001). "Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenvironment.". J. Biol. Chem. 275 (51): 40453–62. doi:10.1074/jbc.M006412200. PMID 11013244. 
  • Kataoka H, Meng JY, Itoh H, et al. (2001). "Localization of hepatocyte growth factor activator inhibitor type 1 in Langhans' cells of human placenta.". Histochem. Cell Biol. 114 (6): 469–75. PMID 11201608. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources.". Mol. Cell Proteomics 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574. 
  • Tjin EP, Derksen PW, Kataoka H, et al. (2004). "Multiple myeloma cells catalyze hepatocyte growth factor (HGF) activation by secreting the serine protease HGF-activator.". Blood 104 (7): 2172–5. doi:10.1182/blood-2003-12-4386. PMID 15172968. 
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161. 
  • Shia S, Stamos J, Kirchhofer D, et al. (2005). "Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B.". J. Mol. Biol. 346 (5): 1335–49. doi:10.1016/j.jmb.2004.12.048. PMID 15713485. 
  • Tjin EP, Groen RW, Vogelzang I, et al. (2006). "Functional analysis of HGF/MET signaling and aberrant HGF-activator expression in diffuse large B-cell lymphoma.". Blood 107 (2): 760–8. doi:10.1182/blood-2005-05-1929. PMID 16189274. 
  • Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952. 
 This article on a gene on chromosome 4 is a stub. You can help Wikipedia by expanding it.