TMEFF2

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Transmembrane protein with EGF-like and two follistatin-like domains 2
Identifiers
Symbol(s) TMEFF2; TR; HPP1; TENB2; TPEF
External IDs OMIM: 605734 MGI: 1861735 HomoloGene: 9417
Orthologs
Human Mouse
Entrez 23671 56363
Ensembl ENSG00000144339 ENSMUSG00000026109
Uniprot Q9UIK5 Q9QYM9
Refseq NM_016192 (mRNA)
NP_057276 (protein)		 NM_019790 (mRNA)
NP_062764 (protein)
Location Chr 2: 192.52 - 192.77 Mb Chr 1: 50.87 - 51.13 Mb
Pubmed search [1] [2]

Transmembrane protein with EGF-like and two follistatin-like domains 2, also known as TMEFF2, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2.

[edit] Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149. 
  • Uchida T, Wada K, Akamatsu T, et al. (2000). "A novel epidermal growth factor-like molecule containing two follistatin modules stimulates tyrosine phosphorylation of erbB-4 in MKN28 gastric cancer cells.". Biochem. Biophys. Res. Commun. 266 (2): 593-602. doi:10.1006/bbrc.1999.1873. PMID 10600548. 
  • Horie M, Mitsumoto Y, Kyushiki H, et al. (2000). "Identification and characterization of TMEFF2, a novel survival factor for hippocampal and mesencephalic neurons.". Genomics 67 (2): 146-52. doi:10.1006/geno.2000.6228. PMID 10903839. 
  • Liang G, Robertson KD, Talmadge C, et al. (2000). "The gene for a novel transmembrane protein containing epidermal growth factor and follistatin domains is frequently hypermethylated in human tumor cells.". Cancer Res. 60 (17): 4907-12. PMID 10987305. 
  • Young J, Biden KG, Simms LA, et al. (2001). "HPP1: a transmembrane protein-encoding gene commonly methylated in colorectal polyps and cancers.". Proc. Natl. Acad. Sci. U.S.A. 98 (1): 265-70. doi:10.1073/pnas.011415298. PMID 11120884. 
  • Glynne-Jones E, Harper ME, Seery LT, et al. (2001). "TENB2, a proteoglycan identified in prostate cancer that is associated with disease progression and androgen independence.". Int. J. Cancer 94 (2): 178-84. PMID 11668495. 
  • Shibata DM, Sato F, Mori Y, et al. (2002). "Hypermethylation of HPP1 is associated with hMLH1 hypermethylation in gastric adenocarcinomas.". Cancer Res. 62 (20): 5637-40. PMID 12384516. 
  • Sato F, Shibata D, Harpaz N, et al. (2003). "Aberrant methylation of the HPP1 gene in ulcerative colitis-associated colorectal carcinoma.". Cancer Res. 62 (23): 6820-2. PMID 12460892. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gery S, Koeffler HP (2003). "Repression of the TMEFF2 promoter by c-Myc.". J. Mol. Biol. 328 (5): 977-83. PMID 12729735. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Sabbioni S, Miotto E, Veronese A, et al. (2004). "Multigene methylation analysis of gastrointestinal tumors: TPEF emerges as a frequent tumor-specific aberrantly methylated marker that can be detected in peripheral blood.". Mol. Diagn. 7 (3-4): 201-7. PMID 15068392. 
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819-24. doi:10.1110/ps.04682504. PMID 15340161. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724-31. doi:10.1038/nature03466. PMID 15815621. 
  • Schulmann K, Sterian A, Berki A, et al. (2005). "Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression risk.". Oncogene 24 (25): 4138-48. doi:10.1038/sj.onc.1208598. PMID 15824739. 
  • Suzuki M, Shigematsu H, Shames DS, et al. (2005). "DNA methylation-associated inactivation of TGFbeta-related genes DRM/Gremlin, RUNX3, and HPP1 in human cancers.". Br. J. Cancer 93 (9): 1029-37. doi:10.1038/sj.bjc.6602837. PMID 16234815. 
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117-26. doi:10.1093/dnares/12.2.117. PMID 16303743. 
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