LRP5

From Wikipedia, the free encyclopedia

Low density lipoprotein receptor-related protein 5

Identifiers

LRP5; HBM; BMND1; EVR1; EVR4; LR3; LRP7; OPPG; OPS; OPTA1; VBCH2

External IDs

OMIM: 603506 MGI: 1278315 HomoloGene: 1746

Gene ontology
Molecular Function:	• receptor activity
Cellular Component:	• membrane • integral to membrane
Biological Process:	• lipid metabolic process • endocytosis • signal transduction • multicellular organismal development • positive regulation of cell proliferation • Wnt receptor signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002335 (mRNA)
NP_002326 (protein)

NM_008513 (mRNA)
NP_032539 (protein)

Location

Chr 11: 67.84 - 67.97 Mb

Chr 19: 3.58 - 3.69 Mb

Pubmed search

[1]

[2]

Low density lipoprotein receptor-related protein 5, also known as LRP5, is a human gene.^[1]

[edit] References

^ Entrez Gene: LRP5 low density lipoprotein receptor-related protein 5.

[edit] Further reading

He X, Semenov M, Tamai K, Zeng X (2004). "LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way.". Development 131 (8): 1663-77. doi:10.1242/dev.01117. PMID 15084453.
Godyna S, Liau G, Popa I, et al. (1995). "Identification of the low density lipoprotein receptor-related protein (LRP) as an endocytic receptor for thrombospondin-1.". J. Cell Biol. 129 (5): 1403-10. PMID 7775583.
Gong Y, Vikkula M, Boon L, et al. (1996). "Osteoporosis-pseudoglioma syndrome, a disorder affecting skeletal strength and vision, is assigned to chromosome region 11q12-13.". Am. J. Hum. Genet. 59 (1): 146-51. PMID 8659519.
Johnson ML, Gong G, Kimberling W, et al. (1997). "Linkage of a gene causing high bone mass to human chromosome 11 (11q12-13)". Am. J. Hum. Genet. 60 (6): 1326-32. PMID 9199553.
Hey PJ, Twells RC, Phillips MS, et al. (1998). "Cloning of a novel member of the low-density lipoprotein receptor family.". Gene 216 (1): 103-11. PMID 9714764.
Dong Y, Lathrop W, Weaver D, et al. (1998). "Molecular cloning and characterization of LR3, a novel LDL receptor family protein with mitogenic activity.". Biochem. Biophys. Res. Commun. 251 (3): 784-90. doi:10.1006/bbrc.1998.9545. PMID 9790987.
de Crecchio G, Simonelli F, Nunziata G, et al. (1999). "Autosomal recessive familial exudative vitreoretinopathy: evidence for genetic heterogeneity.". Clin. Genet. 54 (4): 315-20. PMID 9831343.
Chen D, Lathrop W, Dong Y (1999). "Molecular cloning of mouse Lrp7(Lr3) cDNA and chromosomal mapping of orthologous genes in mouse and human.". Genomics 55 (3): 314-21. doi:10.1006/geno.1998.5688. PMID 10049586.
Mao J, Wang J, Liu B, et al. (2001). "Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway.". Mol. Cell 7 (4): 801-9. PMID 11336703.
Twells RC, Metzker ML, Brown SD, et al. (2001). "The sequence and gene characterization of a 400-kb candidate region for IDDM4 on chromosome 11q13.". Genomics 72 (3): 231-42. doi:10.1006/geno.2000.6492. PMID 11401438.
Semënov MV, Tamai K, Brott BK, et al. (2001). "Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.". Curr. Biol. 11 (12): 951-61. PMID 11448771.
Zorn AM (2001). "Wnt signalling: antagonistic Dickkopfs.". Curr. Biol. 11 (15): R592-5. PMID 11516963.
Gong Y, Slee RB, Fukai N, et al. (2002). "LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development.". Cell 107 (4): 513-23. PMID 11719191.
Little RD, Carulli JP, Del Mastro RG, et al. (2002). "A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait.". Am. J. Hum. Genet. 70 (1): 11-9. PMID 11741193.
Okubo M, Horinishi A, Kim DH, et al. (2002). "Seven novel sequence variants in the human low density lipoprotein receptor related protein 5 (LRP5) gene.". Hum. Mutat. 19 (2): 186. doi:10.1002/humu.9012. PMID 11793484.
Boyden LM, Mao J, Belsky J, et al. (2002). "High bone density due to a mutation in LDL-receptor-related protein 5.". N. Engl. J. Med. 346 (20): 1513-21. doi:10.1056/NEJMoa013444. PMID 12015390.
Van Hul E, Gram J, Bollerslev J, et al. (2002). "Localization of the gene causing autosomal dominant osteopetrosis type I to chromosome 11q12-13.". J. Bone Miner. Res. 17 (6): 1111-7. PMID 12054167.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Fujino T, Asaba H, Kang MJ, et al. (2003). "Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion.". Proc. Natl. Acad. Sci. U.S.A. 100 (1): 229-34. doi:10.1073/pnas.0133792100. PMID 12509515.
Van Wesenbeeck L, Cleiren E, Gram J, et al. (2003). "Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density.". Am. J. Hum. Genet. 72 (3): 763-71. PMID 12579474.