| County |
Location |
Mile[2] |
# |
Destinations |
Notes |
| Franklin |
State Line |
Maryland state line. I-81 south continues into Maryland. |
| 0.00 |
1 |
PA 163 — Mason Dixon Road |
|
| Antrim Township |
2.51 |
3 |
US 11 — Molly Pitcher Highway |
|
| Greencastle |
4.76 |
5 |
PA 16 — Greencastle, Waynesboro |
to Mercersburg. |
| Guilford Township |
9.72 |
10 |
PA 914 — Marion |
|
| Hamilton Township |
14.22 |
14 |
PA 316 — Wayne Avenue |
|
| Chambersburg |
15.65 |
16 |
US 30 (Lincoln Way) — Chambersburg |
To Gettysburg and Wilson College. |
| Greene Township |
16.95 |
17 |
Walker Road |
|
| 19.98 |
20 |
PA 997 — Scotland |
Penn State- Mont Alto. |
| 24.19 |
24 |
PA 696 — Fayette Street |
|
| Cumberland |
Southampton Township |
28.54 |
29 |
PA 174 — King Street |
Shippensburg Airport. Shippensburg University. |
| Penn Township |
36.92 |
37 |
PA 233 — Newville |
|
| Carlisle |
44.02 |
44 |
PA 465 — Plainfield |
Carlisle Fairgrounds. |
| 45.61 |
45 |
College Street |
Penn State Dickinson School of Law. |
| 46.51 |
47 |
PA 34 — Hanover Street |
U.S. Army War College. |
| 47.82 |
48 |
PA 74 — York Road |
Northbound only. |
| 48.68 |
49 |
PA 641 — High Street |
|
| Middlesex Township |
51.61 |
52 |
 
  US 11 – I-76/PA Turnpike — New Kingstown, Middlesex |
Carlisle exit on I-76/PA Turnpike. |
| Silver Spring Township |
56.80 |
57 |
PA 114 — Mechanicsburg |
|
| Hampden Township |
Southern terminus of I-81/ Capital Beltway concurrency. |
| 59.13 |
59 |
 
 PA 581 (Harrisburg Expressway) east – US 11, Camp Hill |
Capital Beltway. |
| 60.85 |
61 |
PA 944 — Wertzville Road |
|
| East Pennsboro Township |
64.78 |
65 |
 US 11 – US 15 — Enola, Marysville |
Central Pennsylvania College. |
| Dauphin |
Harrisburg |
65.97 |
66 |
Front Street — Downtown Harrisburg |
Amtrak Terminal. |
| 67.13 |
67A |
 
 US 22 east — (Cameron Street) PA 230 |
Harrisburg Area Community College. |
| 67B |
 US 22 west – US 322 west — Lewistown, State College |
|
Southern terminus of I-81/ US 322 concurrency. |
| 68.70 |
69 |
Progress Avenue |
Widener University. |
| Colonial Park |
Northern terminus of I-81/ US 322 concurrency.
Northern terminus of I-81/ Capital Beltway concurrency. |
| 69.70 |
70 |
 I-83 south/US 322 east - Hershey, York |
Capital Beltway. Harrisburg Airport. |
| Paxtonia |
72.44 |
72 |

US 22 — Paxtonia, Linglestown |
|
| West Hanover Township |
76.72 |
77 |
PA 39 — Manada Hill, Hershey |
Hershey Attractions. |
| East Hanover Township |
80.45 |
80 |
 
PA 743 — Grantville, Hershey |
|
| Lebanon |
East Hanover Township |
85.32 |
85 |
PA 934 south — Annville, Fort Indiantown Gap |
Lebanon Valley College. |
| Union Township |
88.74 |
89 |

I-78 east — Allentown, New York City. |
|
| 90.52 |
90 |
PA 72 — Lebanon |
|
| Schuylkill |
Pine Grove Township |
99.61 |
100 |
PA 443 — Pine Grove |
|
| Tremont Township |
104.21 |
104 |
PA 125 — Ravine |
|
| Frailey Township |
107.06 |
107 |
US 209 — Tremont, Tower City |
|
| 111.63 |
112 |
PA 25 — Hegins |
|
| Foster Township |
116.18 |
116 |
PA 901 — Minersville |
Mount Carmel. |
| Butler Township |
118.67 |
119 |
Highridge Park Road |
to Hecksherville and Gordon |
| Frackville |
123.95 |
124 |
PA 61 — Saint Clair, Frackville |
to Pottsville and Shamokin. |
| Mahanoy Township |
130.92 |
131 |
PA 54 — Hometown, Mahanoy City |
|
| Delano Township |
133.74 |
134 |
Delano |
|
| Kline Township |
137.62 |
138 |
PA 309 — McAdoo, Tamaqua |
|
| Luzerne |
Hazle Township |
141.18 |
141 |
 
 PA 424 east – PA 309 — Hazleton |
|
| 142.75 |
143 |
PA 924 — Hazleton |
|
| Sugarloaf Township |
145.46 |
145 |
PA 93 — West Hazleton |
Penn State University Hazleton Campus. |
| Butler Township |
150.76 |
151 |
I-80 — Bloomsburg, Stroudsburg |
|
| Dorrance |
154.48 |
155 |
Dorrance |
|
| Nuangola |
158.95 |
159 |
Nuangola |
|
| Hanover Township |
164.30 |
164 |
PA 29 (South Cross Valley Expressway) north — Nanticoke |
Luzerne County Cummunity College. |
| Wilkes-Barre |
165.33 |
165 |
 
 PA 309 south – PA 309 BUS — Wilkes-Barre, Mountain Top |
|
Southern terminus of I-81/ PA 309 concurrency. |
| 168.43 |
168 |
Highland Park Boulevard — Wilkes-Barre |
Access to Wachovia Arena and Downtown Wilkes-Barre. |
| Plains Township |
Northern terminus of I-81/ PA 309 concurrency. |
| 169.95 |
170 |
 PA 115 south – PA 309 (North Cross Valley Expressway) north - Bear Creek, Wilkes-Barre |
Access to King's College and Wilkes University. |
| Pittstown Township |
175.02 |
175 |
 
  PA 315 – I-476/PA Turnpike — Pittston, Dupont |
Wilkes-Barre exit of PA Turnpike Northeast Extension. |
| Avoca |
177.54 |
178 |
PA 315 — Avoca, Wilkes-Barre/Scranton International Airport |
|
| Lackawanna |
Moosic |
179.31 |
180 |
 
 US 11 – PA 502 — Moosic |
Southbound exit no US11 Northbound Access; Southbound US11 and PA502 Only |
| Scranton |
181.57 |
182 |
Montage Mountain Road, Davis Street |
|
| 184.04 |
184 |
 
PA 307 — River Street |
Northbound only. |
| 184 |
PA 307 — Moosic Street |
Southbound only. |
| 184.36 |
185 |
Central Scranton Expressway |
Access to Scranton Memorial Stadium and University of Scranton. |
| Dunmore |
186.49 |
186 |
Drinker Street |
Northbound only. |
| 187.04 |
187 |
  I-84 east – I-380 south – US 6 east — Milford, Mt. Pocono, Carbondale |
Throop Dunmore Interchange. |
Southern terminus of I-81/ US 6 concurrency. |
| 188.00 |
188 |
PA 347 — Throop, Dunmore |
Access to Penn State- Worthington Scranton Campus and Marywood University. |
| Scranton |
189.71 |
190 |
Main Street — Dickson City |
|
| 191.00 |
191 |
 
 US 6 BUS – US 11 (North Scranton Expressway) — Dickson City, North Scranton |
|
| South Abington Township |
Northern terminus of I-81/ US 6 concurrency. |
| 193.41 |
194 |
   US 6 west – I-476 south/PA Turnpike south – US 11 — Clarks Summit |
Clarks Summit exit of PA Turnpike Northeast Extension. Northern terminus of Northeast Extension. |
| Scott Township |
197.13 |
197 |
PA 632 — Waverly |
|
| 198.71 |
199 |
PA 524 — Scott |
|
| 200.41 |
201 |
PA 438 — East Benson |
|
| Benton Township |
201.48 |
202 |
PA 107 — Fleetville, Thompkinsville |
|
| Susquehanna |
Lenox Township |
205.74 |
206 |
PA 374 — Glenwood, Lenoxville |
|
| 211.05 |
211 |
— Lenox |
Northbound only. |
| 211 |
PA 92 — Lenox |
Southbound only. |
| Harford Township |
216.42 |
217 |
PA 547 — Harford |
|
| New Milford Township |
218.91 |
219 |
PA 848 — Gibson |
|
| New Milford |
223.12 |
223 |
PA 492 — New Milford, Lakeside |
|
| Hallstead |
230.22 |
230 |
PA 171 — Great Bend, Susquehanna |
Last exit in Pennsylvania. |
New York state line. I-81 north continues into New York. |