IMP dehydrogenase

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IMP (inosine monophosphate) dehydrogenase 1
Identifiers
Symbol	IMPDH1
Alt. Symbols	RP10
Entrez	3614
HUGO	6052
OMIM	146690
RefSeq	NM_000883
UniProt	P20839
Other data
EC number	1.1.1.205
Locus	Chr. 7 q31.3-q32

IMP (inosine monophosphate) dehydrogenase 2
Identifiers
Symbol	IMPDH2
Entrez	3615
HUGO	6053
OMIM	146691
RefSeq	NM_000884
UniProt	P12268
Other data
EC number	1.1.1.205
Locus	Chr. 3 p21.2

IMP dehydrogenase is an enzyme which converts inosine monophosphate to xanthosine monophosphate.

inosine 5'-phosphate + NAD⁺ + H₂O —–> xanthosine 5'-phosphate + NADH + H⁺

[edit] See also

• Purine metabolism

[edit] References

• IUBMB entry for 1.1.1.205
• BRENDA references for 1.1.1.205 (Recommended.)
• PubMed references for 1.1.1.205
• PubMed Central references for 1.1.1.205
• Google Scholar references for 1.1.1.205

[edit] External links

• IUBMB entry for 1.1.1.205

• KEGG entry for 1.1.1.205

• BRENDA entry for 1.1.1.205

• NiceZyme view of 1.1.1.205

• EC2PDB: PDB structures for 1.1.1.205

• PRIAM entry for 1.1.1.205

• PUMA2 entry for 1.1.1.205

• IntEnz: Integrated Enzyme entry for 1.1.1.205

• MetaCyc entry for 1.1.1.205

• Atomic-resolution structures of enzymes belonging to this class

v • d • e Oxidoreductases: alcohol oxidoreductases (EC 1.1) 1.1.1 NAD/NADP acceptor Carbohydrate dehydrogenases - Alcohol dehydrogenase - Glycerol-3-phosphate dehydrogenase - L-xylulose reductase - Aldose reductase - Lactate dehydrogenase - 3-Hydroxyacyl CoA dehydrogenase - Malate dehydrogenase - Isocitrate dehydrogenase - Phosphogluconate dehydrogenase - Glucose-6-phosphate dehydrogenase - HMG-CoA reductase - Β-Ketoacyl ACP reductase - Hydroxysteroid dehydrogenase: 11 Beta (HSD11B1, HSD11B2) - 3 Beta (3-beta-HSD) - 17 Beta - Carnitine dehydrogenase - Beta-hydroxybutyryl-CoA dehydrogenase - IMP dehydrogenase - DXP reductoisomerase - L-threonine dehydrogenase 1.1.2 cytochrome acceptor Mannitol dehydrogenase (cytochrome) - D-lactate dehydrogenase (cytochrome) - D-lactate dehydrogenase (cytochrome c-553) 1.1.3 oxygen acceptor Glucose oxidase - L-gulonolactone oxidase - Xanthine oxidase 1.1.4 disulfide as acceptor Vitamin K epoxide reductase - Vitamin-K-epoxide reductase (warfarin-insensitive) 1.1.5 quinone/similar acceptor Quinoprotein glucose dehydrogenase 1.1.99 other acceptors Choline dehydrogenase

v • d • e Metabolism: amino acid metabolism - nucleotide enzymes Purine anabolism synthesis: Amidophosphoribosyltransferase - Inosine monophosphate synthase GMP (IMP dehydrogenase, GMP synthase, GMP reductase) AMP (Adenylosuccinate synthase, Adenylosuccinate lyase, AMP deaminase) Purine catabolism Adenosine deaminase - Purine nucleoside phosphorylase - Guanine deaminase - Xanthine oxidase - Urate oxidase Nucleotide salvage Hypoxanthine-guanine phosphoribosyltransferase - Adenine phosphoribosyltransferase Pyrimidine metabolism CAD (Carbamoyl phosphate synthase II, Aspartate carbamoyltransferase, Dihydroorotase) - Dihydroorotate dehydrogenase - Orotidine 5'-phosphate decarboxylase - CTP synthase - Dihydropyrimidine dehydrogenase Deoxyribonucleotide Ribonucleotide reductase - Nucleoside-diphosphate kinase - DCMP deaminase - Thymidylate synthase - Dihydrofolate reductase see also disorders