Amidophosphoribosyltransferase

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phosphoribosyl pyrophosphate amidotransferase
Identifiers
Symbol	PPAT
Entrez	5471
HUGO	9238
OMIM	172450
RefSeq	NM_002703
UniProt	Q06203
Other data
EC number	2.4.2.14
Locus	Chr. 4 pter-q21

Amidophosphoribosyltransferase (or phosphoribosyl pyrophosphate amidotransferase) is an enzyme which converts phosphoribosylpyrophosphate (PRPP) into 5-phosphoribosylamine. The enzyme uses the ammonia group from the glutamine side chain

PRPP	5-phosphoribosylamine

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MeSH Amidophosphoribosyltransferase

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v • d • e Transferases: glycosyltransferases (EC 2.4)

2.4.1 - Hexosyltransferases: glucosyltransferase	Phosphorylase (Starch, Glycogen, Myo-) - Glycogen synthase - Debranching enzyme - Branching enzyme - 1,3-beta-glucan synthase - Ceramide glucosyltransferase

2.4.1 - Hexosyltransferases: other	Galactosyltransferase (Lactose synthase, B-N-acetylglucosaminyl-glycopeptide b-1,4-galactosyltransferase) Glucuronosyltransferase (UGT1A1, UGT2B7, Hyaluronan synthase) Fucosyltransferase (POFUT1, POFUT2)

2.4.2 - Pentosyltransferases: ADP ribose	Cholera toxin - Diphtheria toxin - Pertussis toxin - Poly ADP ribose polymerase

2.4.2 - Pentosyltransferases: other	Purine nucleoside phosphorylase - Adenine phosphoribosyltransferase - Hypoxanthine-guanine phosphoribosyltransferase - Uracil phosphoribosyltransferase - Amidophosphoribosyltransferase - Xylosyltransferase

v • d • e

Metabolism: amino acid metabolism - nucleotide enzymes

Purine metabolism

Anabolism	R5P->IMP: Ribose-phosphate diphosphokinase - Amidophosphoribosyltransferase - Phosphoribosylglycinamide formyltransferase - AIR synthetase (FGAM cyclase) - Phosphoribosylaminoimidazole carboxylase - Phosphoribosylaminoimidazolesuccinocarboxamide synthase - IMP synthase IMP->AMP: Adenylosuccinate synthase - Adenylosuccinate lyase - reverse (AMP deaminase) IMP->GMP: IMP dehydrogenase - GMP synthase - reverse (GMP reductase)

Nucleotide salvage	Hypoxanthine-guanine phosphoribosyltransferase - Adenine phosphoribosyltransferase

Catabolism	Adenosine deaminase - Purine nucleoside phosphorylase - Guanine deaminase - Xanthine oxidase - Urate oxidase

Pyrimidine metabolism

Anabolism	CAD (Carbamoyl phosphate synthase II, Aspartate carbamoyltransferase, Dihydroorotase) Dihydroorotate dehydrogenase - Orotidine 5'-phosphate decarboxylase/Uridine monophosphate synthetase CTP synthase

Catabolism	Dihydropyrimidine dehydrogenase - Dihydropyrimidinase/DPYS - Beta-ureidopropionase/UPB1