GDP-fucose protein O-fucosyltransferase 2

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protein O-fucosyltransferase 2
Identifiers
Symbol	POFUT2
Alt. Symbols	C21orf80
Entrez	23275
HUGO	14683
OMIM	610249
RefSeq	NM_133634
UniProt	Q9Y2G5
Other data
Locus	Chr. 21 q22.3

GDP-fucose protein O-fucosyltransferase 2 (POFUT2) is an enzyme responsible for adding fucose sugars in O linkage to serine or threonine residues in Thrombospondin repeats. The protein is an inverting glycosyltransferase, which means that the enzyme uses GDP-β-L-fucose as a donor substrate and transfers the fucose in O linkage to the protein producing fucose-α-O-serine/threonine.

Almost all glycosyltransferases reside in the Golgi apparatus. However, POFUT2 as well as the related enzyme POFUT1 have recently been shown to reside in the endoplasmic reticulum.

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• MeSH POFUT2+protein,+human

v • d • e Transferases: glycosyltransferases (EC 2.4) 2.4.1 - Hexosyltransferases: glucosyltransferase Phosphorylase (Starch, Glycogen, Myo-) - Glycogen synthase - Debranching enzyme - Branching enzyme - 1,3-beta-glucan synthase - Ceramide glucosyltransferase 2.4.1 - Hexosyltransferases: other Galactosyltransferase (Lactose synthase, B-N-acetylglucosaminyl-glycopeptide b-1,4-galactosyltransferase) Glucuronosyltransferase (UGT1A1, UGT2B7, Hyaluronan synthase) Fucosyltransferase (POFUT1, POFUT2) 2.4.2 - Pentosyltransferases: ADP ribose Cholera toxin - Diphtheria toxin - Pertussis toxin - Poly ADP ribose polymerase 2.4.2 - Pentosyltransferases: other Purine nucleoside phosphorylase - Adenine phosphoribosyltransferase - Hypoxanthine-guanine phosphoribosyltransferase - Uracil phosphoribosyltransferase - Amidophosphoribosyltransferase - Xylosyltransferase