UGT2B7

UDP glucuronosyltransferase 2 family, polypeptide B7
Identifiers
Symbol	UGT2B7
Entrez	7364
HUGO	12554
OMIM	600068
RefSeq	NM_001074
UniProt	P16662
Other data
Locus	Chr. 4 q13

UGT2B7 (UDP-Glucuronosyltransferase-2B7) is a phase II metabolism isoenzyme found to be active in the liver, kidneys, epithelial cells of the lower gastrointestinal tract and also has been reported in the brain.

This enzyme is located on the endoplasmic reticulum and nuclear membranes of cells. Its function is to catalyse the conjugation of a wide variety of lipophilic aglycon substrates with glucuronic acid, using uridine diphosphate glucuronic acid.

UGT2B7 is the major enzyme isoform for the metabolism of Morphine to the main metabolites, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G).^[1]

[edit] References

^ Coffman B, Rios G, King C, Tephly T (1997). "Human UGT2B7 catalyzes morphine glucuronidation". Drug Metab. Dispos. 25 (1): 1–4. PMID 9010622.

v • d • e Transferases: glycosyltransferases (EC 2.4)

2.4.1 - Hexosyltransferases: glucosyltransferase	Phosphorylase (Starch, Glycogen, Myo-) - Glycogen synthase - Debranching enzyme - Branching enzyme - 1,3-beta-glucan synthase - Ceramide glucosyltransferase

2.4.1 - Hexosyltransferases: other	Galactosyltransferase (Lactose synthase, B-N-acetylglucosaminyl-glycopeptide b-1,4-galactosyltransferase) Glucuronosyltransferase (UGT1A1, UGT2B7, Hyaluronan synthase) Fucosyltransferase (POFUT1, POFUT2)

2.4.2 - Pentosyltransferases: ADP ribose	Cholera toxin - Diphtheria toxin - Pertussis toxin - Poly ADP ribose polymerase

2.4.2 - Pentosyltransferases: other	Purine nucleoside phosphorylase - Adenine phosphoribosyltransferase - Hypoxanthine-guanine phosphoribosyltransferase - Uracil phosphoribosyltransferase - Amidophosphoribosyltransferase - Xylosyltransferase