Beta-ureidopropionase

From Wikipedia, the free encyclopedia

In enzymology, a beta-ureidopropionase (EC 3.5.1.6) is an enzyme that catalyzes the chemical reaction

N-carbamoyl-beta-alanine + H₂O beta-alanine + CO₂ + NH₃

Thus, the two substrates of this enzyme are N-carbamoyl-beta-alanine and H₂O, whereas its 3 products are beta-alanine, CO₂, and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-carbamoyl-beta-alanine amidohydrolase. This enzyme participates in 3 metabolic pathways: pyrimidine metabolism, beta-alanine metabolism, and pantothenate and coa biosynthesis.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1R3N, 1R43, 2V8D, 2V8G, 2V8H, and 2V8V.

[edit] References

• IUBMB entry for 3.5.1.6
• BRENDA references for 3.5.1.6 (Recommended.)
• PubMed references for 3.5.1.6
• PubMed Central references for 3.5.1.6
• Google Scholar references for 3.5.1.6
• CAMPBELL LL (1960). "Reductive degradation of pyrimidines. 5. Enzymatic conversion of N-carbamyl-beta-alanine to beta-alanine, carbon dioxide, and ammonia". J. Biol. Chem. 235: 2375–8. PMID 13849303. 
• CARAVACA J, GRISOLIA S (1958). "Enzymatic decarbamylation of carbamyl beta-alanine and carbamyl beta-aminoisobutyric acid". J. Biol. Chem. 231: 357–65. PMID 13538975. 
• Traut TW, Loechel S (1984). "Pyrimidine catabolism: individual characterization of the three sequential enzymes with a new assay". Biochemistry. 23: 2533–9. doi:10.1021/bi00306a033. PMID 6433973. 

[edit] External links

The CAS registry number for this enzyme class is 9027-27-4.

• IUBMB entry for 3.5.1.6

• KEGG entry for 3.5.1.6

• BRENDA entry for 3.5.1.6

• NiceZyme view of 3.5.1.6

• EC2PDB: PDB structures for 3.5.1.6

• PRIAM entry for 3.5.1.6

• PUMA2 entry for 3.5.1.6

• IntEnz: Integrated Enzyme entry for 3.5.1.6

• MetaCyc entry for 3.5.1.6

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0003837: beta-ureidopropionase

• AMIGO entry for GO code 0003837: beta-ureidopropionase

v • d • e Metabolism: amino acid metabolism - nucleotide enzymes Purine metabolism Anabolism synthesis: Amidophosphoribosyltransferase - Inosine monophosphate synthase GMP (IMP dehydrogenase, GMP synthase, GMP reductase) AMP (Adenylosuccinate synthase, Adenylosuccinate lyase, AMP deaminase) Nucleotide salvage Hypoxanthine-guanine phosphoribosyltransferase - Adenine phosphoribosyltransferase Catabolism Adenosine deaminase - Purine nucleoside phosphorylase - Guanine deaminase - Xanthine oxidase - Urate oxidase Pyrimidine metabolism Anabolism CAD (Carbamoyl phosphate synthase II, Aspartate carbamoyltransferase, Dihydroorotase) Dihydroorotate dehydrogenase - Orotidine 5'-phosphate decarboxylase/Uridine monophosphate synthetase CTP synthase Catabolism Dihydropyrimidine dehydrogenase - Dihydropyrimidinase/DPYS - Beta-ureidopropionase/UPB1 Deoxyribonucleotides Ribonucleotide reductase - Nucleoside-diphosphate kinase - DCMP deaminase - Thymidylate synthase - Dihydrofolate reductase see also disorders, intermediates