D-lactate dehydrogenase (cytochrome)

From Wikipedia, the free encyclopedia

In enzymology, a D-lactate dehydrogenase (cytochrome) (EC 1.1.2.4) is an enzyme that catalyzes the chemical reaction

(R)-lactate + 2 ferricytochrome c pyruvate + 2 ferrocytochrome c

Thus, the two substrates of this enzyme are (R)-lactate and ferricytochrome c, whereas its two products are pyruvate and ferrocytochrome c.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with a cytochrome as acceptor. The systematic name of this enzyme class is (R)-lactate:ferricytochrome-c 2-oxidoreductase. Other names in common use include lactic acid dehydrogenase, D-lactate (cytochrome) dehydrogenase, cytochrome-dependent D-(-)-lactate dehydrogenase, D-lactate-cytochrome c reductase, and D-(-)-lactic cytochrome c reductase. This enzyme participates in pyruvate metabolism. It employs one cofactor, FAD.

[edit] References

• IUBMB entry for 1.1.2.4
• BRENDA references for 1.1.2.4 (Recommended.)
• PubMed references for 1.1.2.4
• PubMed Central references for 1.1.2.4
• Google Scholar references for 1.1.2.4
• GREGOLIN C, SINGER TP (1963). "The lactic dehydrogenase of yeast. III. D(-)Lactic cytochrome c reductase, a zinc-flavoprotein from aerobic yeast". Biochim. Biophys. Acta. 67: 201–18. doi:10.1016/0006-3002(63)91818-3. PMID 13950255. 
• GREGOLIN C, SINGER TP, KEARNEY EB, BOERI E (1961). "The formation and enzymatic properties of the various lactic dehydrogenases of yeast". Ann. N. Y. Acad. Sci. 94: 780–97. doi:10.1111/j.1749-6632.1961.tb35573.x. PMID 13901630. 
• Nygaard AP (1961). "D(-)-Lactate cytochrome c reductase, a flavoprotein from yeast". J. Biol. Chem. 236: 920–925. 
• Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 557-565.

[edit] External links

The CAS registry number for this enzyme class is 37250-79-6.

• IUBMB entry for 1.1.2.4

• KEGG entry for 1.1.2.4

• BRENDA entry for 1.1.2.4

• NiceZyme view of 1.1.2.4

• EC2PDB: PDB structures for 1.1.2.4

• PRIAM entry for 1.1.2.4

• PUMA2 entry for 1.1.2.4

• IntEnz: Integrated Enzyme entry for 1.1.2.4

• MetaCyc entry for 1.1.2.4

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004458: D-lactate dehydrogenase (cytochrome)

• AMIGO entry for GO code 0004458: D-lactate dehydrogenase (cytochrome)

v • d • e Oxidoreductases: alcohol oxidoreductases (EC 1.1) 1.1.1 NAD/NADP acceptor Carbohydrate dehydrogenases - Alcohol dehydrogenase - Glycerol-3-phosphate dehydrogenase - L-xylulose reductase - Aldose reductase - Lactate dehydrogenase - 3-Hydroxyacyl CoA dehydrogenase - Malate dehydrogenase - Isocitrate dehydrogenase - Phosphogluconate dehydrogenase - Glucose-6-phosphate dehydrogenase - HMG-CoA reductase - Β-Ketoacyl ACP reductase - Hydroxysteroid dehydrogenase: 11 Beta (HSD11B1, HSD11B2) - 3 Beta (3-beta-HSD) - 17 Beta - Carnitine dehydrogenase - Beta-hydroxybutyryl-CoA dehydrogenase - IMP dehydrogenase - DXP reductoisomerase - L-threonine dehydrogenase 1.1.2 cytochrome acceptor Mannitol dehydrogenase (cytochrome) - D-lactate dehydrogenase (cytochrome) - D-lactate dehydrogenase (cytochrome c-553) 1.1.3 oxygen acceptor Glucose oxidase - L-gulonolactone oxidase - Xanthine oxidase 1.1.4 disulfide as acceptor Vitamin K epoxide reductase - Vitamin-K-epoxide reductase (warfarin-insensitive) 1.1.5 quinone/similar acceptor Quinoprotein glucose dehydrogenase 1.1.99 other acceptors Choline dehydrogenase