Mannitol dehydrogenase (cytochrome)

From Wikipedia, the free encyclopedia

In enzymology, a mannitol dehydrogenase (cytochrome) (EC 1.1.2.2) is an enzyme that catalyzes the chemical reaction

D-mannitol + ferricytochrome c D-fructose + ferrocytochrome c

Thus, the two substrates of this enzyme are D-mannitol and ferricytochrome c, whereas its two products are D-fructose and ferrocytochrome c.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with a cytochrome as acceptor. The systematic name of this enzyme class is D-mannitol:ferricytochrome-c 2-oxidoreductase. This enzyme is also called polyol dehydrogenase. This enzyme participates in pentose and glucuronate interconversions and fructose and mannose metabolism.

[edit] References

• IUBMB entry for 1.1.2.2
• BRENDA references for 1.1.2.2 (Recommended.)
• PubMed references for 1.1.2.2
• PubMed Central references for 1.1.2.2
• Google Scholar references for 1.1.2.2
• ARCUS AC, EDSON NL (1956). "Polyol dehydrogenases. 2. The polyol dehydrogenases of Acetobacter suboxydans and Candida utilis". Biochem. J. 64: 385–94. PMID 13373782. 
• Cho NC, Kim K and Jhon DY (1990). "Purification and characterization of polyol dehydrogenase from Gluconobacter melanogenus". Han'guk Saenghwa Hakhaochi 23: 172–178. 

[edit] External links

The CAS registry number for this enzyme class is 37250-78-5.

• IUBMB entry for 1.1.2.2

• KEGG entry for 1.1.2.2

• BRENDA entry for 1.1.2.2

• NiceZyme view of 1.1.2.2

• EC2PDB: PDB structures for 1.1.2.2

• PRIAM entry for 1.1.2.2

• PUMA2 entry for 1.1.2.2

• IntEnz: Integrated Enzyme entry for 1.1.2.2

• MetaCyc entry for 1.1.2.2

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050087: mannitol dehydrogenase (cytochrome)

• AMIGO entry for GO code 0050087: mannitol dehydrogenase (cytochrome)

v • d • e Oxidoreductases: alcohol oxidoreductases (EC 1.1) 1.1.1 NAD/NADP acceptor Carbohydrate dehydrogenases - Alcohol dehydrogenase - Glycerol-3-phosphate dehydrogenase - L-xylulose reductase - Aldose reductase - Lactate dehydrogenase - 3-Hydroxyacyl CoA dehydrogenase - Malate dehydrogenase - Isocitrate dehydrogenase - Phosphogluconate dehydrogenase - Glucose-6-phosphate dehydrogenase - HMG-CoA reductase - Β-Ketoacyl ACP reductase - Hydroxysteroid dehydrogenase: 11 Beta (HSD11B1, HSD11B2) - 3 Beta (3-beta-HSD) - 17 Beta - Carnitine dehydrogenase - Beta-hydroxybutyryl-CoA dehydrogenase - IMP dehydrogenase - DXP reductoisomerase - L-threonine dehydrogenase 1.1.2 cytochrome acceptor Mannitol dehydrogenase (cytochrome) - D-lactate dehydrogenase (cytochrome) - D-lactate dehydrogenase (cytochrome c-553) 1.1.3 oxygen acceptor Glucose oxidase - L-gulonolactone oxidase - Xanthine oxidase 1.1.4 disulfide as acceptor Vitamin K epoxide reductase - Vitamin-K-epoxide reductase (warfarin-insensitive) 1.1.5 quinone/similar acceptor Quinoprotein glucose dehydrogenase 1.1.99 other acceptors Choline dehydrogenase