3-Hydroxyacyl CoA dehydrogenase

From Wikipedia, the free encyclopedia

hydroxyacyl-Coenzyme A dehydrogenase
Identifiers
Symbol	HADH
Alt. Symbols	HADHSC
Entrez	3033
HUGO	4799
OMIM	601609
RefSeq	NM_005327
UniProt	Q16836
Other data
EC number	1.1.1.35
Locus	Chr. 4 q22-q26

The third step of beta oxidation is the oxidation of L-3-hydroxyacyl CoA by NAD⁺, catalyzed by 3-Hydroxyacyl CoA dehydrogenase. This converts the hydroxyl group into a keto group.

The end product is 3-ketoacyl CoA.

[edit] References

[edit] External links

IUBMB entry for 1.1.1.35

KEGG entry for 1.1.1.35

BRENDA entry for 1.1.1.35

NiceZyme view of 1.1.1.35

EC2PDB: PDB structures for 1.1.1.35

PRIAM entry for 1.1.1.35

PUMA2 entry for 1.1.1.35

IntEnz: Integrated Enzyme entry for 1.1.1.35

MetaCyc entry for 1.1.1.35

Atomic-resolution structures of enzymes belonging to this class

This EC 1.1.1 enzyme-related article is a stub. You can help Wikipedia by expanding it.

This oxidoreductase article is a stub. You can help Wikipedia by expanding it.

v • d • e Oxidoreductases: alcohol oxidoreductases (EC 1.1)

1.1.1 NAD/NADP acceptor	Carbohydrate dehydrogenases - Alcohol dehydrogenase - Glycerol-3-phosphate dehydrogenase - L-xylulose reductase - Aldose reductase - Lactate dehydrogenase - 3-Hydroxyacyl CoA dehydrogenase - Malate dehydrogenase - Isocitrate dehydrogenase - Phosphogluconate dehydrogenase - Glucose-6-phosphate dehydrogenase - HMG-CoA reductase - Β-Ketoacyl ACP reductase - Hydroxysteroid dehydrogenase: 11 Beta (HSD11B1, HSD11B2) - 3 Beta (3-beta-HSD) - 17 Beta - Carnitine dehydrogenase - Beta-hydroxybutyryl-CoA dehydrogenase - IMP dehydrogenase - DXP reductoisomerase - L-threonine dehydrogenase

1.1.2 cytochrome acceptor	Mannitol dehydrogenase (cytochrome) - D-lactate dehydrogenase (cytochrome) - D-lactate dehydrogenase (cytochrome c-553)

1.1.3 oxygen acceptor	Glucose oxidase - L-gulonolactone oxidase - Xanthine oxidase

1.1.4 disulfide as acceptor	Vitamin K epoxide reductase - Vitamin-K-epoxide reductase (warfarin-insensitive)

1.1.5 quinone/similar acceptor	Quinoprotein glucose dehydrogenase

1.1.99 other acceptors	Choline dehydrogenase

v • d • e Metabolism: lipid metabolism - triglyceride and fatty acid enzymes

Lipid production	ATP citrate lyase - Acetyl-CoA carboxylase Fatty acid synthesis/Fatty acid synthase: Beta-ketoacyl-ACP synthase - Β-Ketoacyl ACP reductase - 3-Hydroxyacyl ACP dehydrase - Enoyl ACP reductase triacyl glycerol: Glycerol-3-phosphate dehydrogenase - Thiokinase

Lipid degradation	Acyl transport: Carnitine palmitoyltransferase I - Carnitine-acylcarnitine translocase - Carnitine palmitoyltransferase II Beta oxidation/Mitochondrial trifunctional protein: Acyl CoA dehydrogenase (ACADL, ACADM, ACADS, ACADVL) - Enoyl-CoA hydratase - 3-Hydroxyacyl CoA dehydrogenase - Acetyl-CoA C-acyltransferase to acetyl-CoA: Malonyl-CoA decarboxylase unsaturated (Enoyl CoA isomerase, 2,4 Dienoyl-CoA reductase) odd chain (Propionyl-CoA carboxylase) aldehydes (Long-chain-aldehyde dehydrogenase)

see also disorders