Diethylcathinone

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Diethylcathinone
Systematic (IUPAC) name
2-diethylamino-1-phenyl-propan-1-one
Identifiers
CAS number	90-84-6
ATC code	A08AA03
PubChem	7029
Chemical data
Formula	C13H19NO
Mol. mass	205.30
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	B
Legal status	Schedule IV(US)
Routes	?

Diethylcathinone (also called Diethylpropion and Amfepramone), is a sympathomimetic stimulant drug marketed as an appetite suppressant. It is sold under the brand name Tenuate or Tenuate Dospan, and may also be known as Amfepramone. The popular antidepressant, Wellbutrin (bupropion) is an analogue of this chemical. Both diethylpropion and bupropion have a stimulant effect on the CNS.

Contents 1 Pharmacology 2 Contraindications 3 Side effects 4 See also 5 References

[edit] Pharmacology

Its mechanism of action is similar to other appetite suppressants such as sibutramine, phentermine and dextroamphetamine. Chemically, it is the N,N-diethyl homologue of cathinone and dimethylcathinone. It has been found to be potentially neurotoxic in that it causes long-term depletions of 5-HT similar to MDMA.^[1]

Diethylpropion is manufactured in 25 mg tablets and 75 mg controlled-release tablets (Tenuate, Tepanil Ten-Tab). Diethylpropion is classified as a Schedule IV controlled substance in the United States.

It is also used in the treatment of migraine (off-label).

[edit] Contraindications

• Hypersensitivity to sympathomimetic amines
• Advanced arteriosclerosis or symptomatic cardiovascular disease
• Moderate or severe hypertension
• Hyperthyroidism
• History of drug abuse
• MAO inhibitor use (within 14 days)

[edit] Side effects

Severe

• Insomnia
• Pulmonary hypertension
• Stroke
• Psychosis

Cardiovascular

• Tachycardia, hypertension, arrhythmia, chest pain

Ear, nose, and throat

• Xerostomia, metallic taste

Endocrine

• Changes in libido, gynecomastia, menstrual irregularities

Eye

• Blurred vision

Gastrointestinal

• Nausea/vomiting, constipation, abdominal cramps

Hematological

• Bone marrow depression, agranulocytosis, leukopenia

Neurological

• Tremor

Psychological

• Euphoria, agitation, nervousness, restlessness, dizziness, anxiety, headache, mental depression, seizures

Skin

• Rash, hives, alopecia, ecchymosis

Urogenital and reproductive

• Changes in libido, impotence

[edit] See also

• Methcathinone
• Methylenedioxymethcathinone

[edit] References

1. ^ Kleven et al., unpublished data Methamphetamine-induced Neurotoxicity: Structure Activity Relationships Annals of the New York Academy of Sciences Volume 654, pg 292–301

v • d • e Stimulants Alkylamines Cyclopentamine • Geranamine • Isometheptene • Octodrine • Propylhexedrine • Tuamine Alphapyrrolidinylalkiophenones α-PPP • MDPPP • MDPV • MPHP • MPPP • MOPPP • Pyrovalerone Cholinergics ABT-089 • ABT-418 • Anabasine • Arecoline • Cotinine • Cytisine • Dianicline • Epibatidine • Epiboxidine • GTS-21 • Ispronicline • Nicotine • Rivanicline • Tebanicline • Varenicline Convulsants Bicuculline • DMCM • Gabazine • Pentetrazol • Picrotoxin • Strychnine • Thujone Eugeroics Adrafinil • Armodafinil • Carphedon • Modafinil Phenethylamines 4-Bromomethcathinone • 4-Fluoroamphetamine • 4-Fluoromethamphetamine • 4-Fluoromethcathinone • 4-Methylmethcathinone • 4-MTA • Aletamine • Amfepentorex • Amphechloral • Amphetamine (Dextroamphetamine, Adderall) • Amphetaminil • Benzphetamine • Bupropion • Cathinone • Chlorphentermine • Clenbuterol • Clobenzorex • Clortermine • Diethylpropion • Dimethoxyamphetamine • Dimethylamphetamine • Dimethylcathinone • Ephedrine • Epinephrine • Ethcathinone • Ethylamphetamine • Fenethylline • Fenfluramine • Fenproporex • Furfenorex • Levomethamphetamine • Lisdexamfetamine • MDMA • Mefenorex • Methamphetamine • Methcathinone • Methoxyphedrine • Methylone • Octopamine • Parahydroxyamphetamine • PCA • PIA • PMA • PMEA • PMMA • PPAP • Phendimetrazine • Phenmetrazine • Phentermine • Phenylephrine • Phenylpropanolamine • Propylamphetamine • Pseudoephedrine • Selegiline • Synephrine • Xylopropamine Phenylaminooxazoles 4-Methyl-aminorex • Aminorex • Clominorex • Fenozolone • Fluminorex • Pemoline • Thozalinone Piperazines 2C-B-BZP • BZP • GBR-12783 • GBR-12935 • GBR-13069 • GBR-13098 • GBR-13119 • MeOPP • MBZP • Vanoxerine Piperidines 2-Benzylpiperidine • Desoxypipradrol • Ethylphenidate • HDMP-28 • (-)-Methyl-1-methyl-4β-(2-naphthyl)piperidine-3β-carboxylate • Methylphenidate (Dexmethylphenidate) • Nocaine • Phacetoperane • Pipradrol Tropanes 3-Pseudotropyl-4-fluorobenzoate • Altropane • Brasofensine • CFT (WIN 35,428) • β-CIT (RTI-55) • Cocaethylene • Cocaine • β-CPPIT • Dichloropane (RTI-111) • Difluoropine • FE-β-CPPIT • FP-β-CPPIT • PIT • PTT • RTI-31 • RTI-32 • RTI-51 • RTI-112 • RTI-113 • RTI-121 (IPCIT) • RTI-126 • RTI-150 • RTI-171 • RTI-177 • RTI-336 • Tesofensine • Troparil (β-CPT, WIN 35,065-2) • WF-23 • WF-33 • WF-60 Xanthines Caffeine • Aminophylline • Paraxanthine • Theobromine • Theophylline Others Amineptine • Bemegride • Benzydamine • BPAP • BTQ • Clofenciclan • Cypenamine • Cyprodenate • Diclofensine • Dimethocaine • Diphenyl prolinol • Ethamivan • Fencamfamine • Feprosidnine • Gilutensin • GYKI-52895 • Hexacyclonate • Indanorex • Indatraline • LR-5182 • Mazindol • Mesocarb • Naphthylisopropylamine • Nikethamide • Nomifensine • Phthalimidopropiophenone • Prolintane • Sibutramine • Yohimbine • Zylofuramine See also Sympathomimetic amines

v • d • e Antiobesity preparations (A08) Centrally acting Phentermine - Fenfluramine - Amfepramone - Dexfenfluramine - Mazindol - Cathine - Clobenzorex - Sibutramine - cannabinoids (Rimonabant, Taranabant) Peripherally acting Orlistat